Loading...
Loading...
Of the 11 tracked institutions holding SYRE, 5 have a 3-year clone track record — 5 of them beat the S&P. Average holder's clone alpha: +3.6pt. It's a gauge of who owns the name, not just how many.
Among the 11 tracked institutional investors we monitor, SYRE (SPYRE THERAPEUTICS INC) is held with a combined value of $2.73B across 33,350,279 shares. The largest holder is FMR LLC with a position worth $1.16B (0.05% of their portfolio). ADAGE CAPITAL PARTNERS GP, L.L.C. opened a new position in the most recent quarter. 8 funds increased their holdings. 2 funds reduced their position.
Total Institutional Value
$2.73B
Total Shares Held
33,350,279
Institutional Holders
11
Ranked by estimated dollars moved (share change × implied price). 13F data lags up to 45 days.
| # | Fund | Value↓ | Portfolio % | Change |
|---|---|---|---|---|
| 1 | FMR LLC | $1.16B | 0.05% | +10.6% |
| 2 | BlackRock, Inc. | $577.66M | 0.01% | +17.8% |
| 3 | STATE STREET CORP | $271.44M | 0.01% | +17.3% |
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | $262.87M | 0.03% | +85.2% |
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $152.91M | 0.21% | New |
| 6 | WELLINGTON MANAGEMENT GROUP LLP | $140.41M | 0.02% | -13.3% |
| 7 | VANGUARD GROUP INC | $132.19M | 0.00% | +32.3% |
| 8 | MILLENNIUM MANAGEMENT LLC | $17.46M | 0.01% | +34.1% |
| 9 | ARMISTICE CAPITAL, LLC | $12.22M | 0.34% | +13.8% |
| 10 | CITADEL ADVISORS LLC | $9.15M | 0.01% | -4.7% |
As of the latest SEC 13F filings, FMR LLC is the largest institutional holder of SYRE with a position worth $1.16B, representing 0.05% of their portfolio. In total, 11 institutional investors hold SYRE with a combined value of $2.73B.
In the most recent quarter, 1 fund opened a new position in SYRE. Additionally, 8 increased their holdings and 2 reduced their positions.
Institutional investors hold $2.73B worth of SYRE stock across 11 positions. The largest institutional holder is FMR LLC with $1.16B in holdings.
A 13F filing is a quarterly report required by the SEC from institutional investment managers with over $100 million in assets. It discloses their holdings in U.S. equities. For SYRE, these filings reveal which major funds are accumulating or reducing positions, providing insights into institutional sentiment.
Get notified when hedge funds change their SYRE positions.
Alpha = the manager's 3-year clone return minus the S&P 500. A skilled roster is a stronger tell than a crowded one — though even skilled managers' edge doesn't reliably survive the 13F disclosure lag. Why →
| 2026-08-14 |
SEC Schedule 13D (activist) and 13G (passive) filings for SYRE. Filed when an investor acquires 5%+ ownership.
Last Close
$88.71
2026-09-10
YTD
+190.1%
79% of 52-week range
