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Of the 12 tracked institutions holding SYRE, 4 have a 3-year clone track record — 4 of them beat the S&P. Average holder's clone alpha: +4.4pt. It's a gauge of who owns the name, not just how many.
Among the 12 tracked institutional investors we monitor, SYRE (SPYRE THERAPEUTICS INC) is held with a combined value of $1.46B across 30,386,090 shares. The largest holder is FMR LLC with a position worth $594.23M (0.03% of their portfolio). 7 funds increased their holdings. 3 funds reduced their position.
Total Institutional Value
$1.46B
Total Shares Held
30,386,090
Institutional Holders
12
Ranked by estimated dollars moved (share change × implied price). 13F data lags up to 45 days.
| # | Fund | Value↓ | Portfolio % | Change |
|---|---|---|---|---|
| 1 | FMR LLC | $594.23M | 0.03% | +1.2% |
| 2 | BlackRock, Inc. | $278.49M | 0.00% | -0.0% |
| 3 | VANGUARD GROUP INC | $132.19M | 0.00% | +32.3% |
| 4 | STATE STREET CORP | $131.50M | 0.00% | +15.2% |
| 5 | WELLINGTON MANAGEMENT GROUP LLP | $92.04M | 0.02% | +17.8% |
| 6 | RA CAPITAL MANAGEMENT, L.P. | $81.79M | 0.87% | - |
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | $80.64M | 0.01% | -0.2% |
| 8 | BAKER BROS. ADVISORS LP | $50.44M | 0.29% | - |
| 9 | MILLENNIUM MANAGEMENT LLC | $7.40M | 0.00% | +92.5% |
| 10 | ARMISTICE CAPITAL, LLC | $6.10M | 0.20% | -38.4% |
As of the latest SEC 13F filings, FMR LLC is the largest institutional holder of SYRE with a position worth $594.23M, representing 0.03% of their portfolio. In total, 12 institutional investors hold SYRE with a combined value of $1.46B.
Institutional investors hold $1.46B worth of SYRE stock across 12 positions. The largest institutional holder is FMR LLC with $594.23M in holdings.
A 13F filing is a quarterly report required by the SEC from institutional investment managers with over $100 million in assets. It discloses their holdings in U.S. equities. For SYRE, these filings reveal which major funds are accumulating or reducing positions, providing insights into institutional sentiment.
Get notified when hedge funds change their SYRE positions.
Alpha = the manager's 3-year clone return minus the S&P 500. A skilled roster is a stronger tell than a crowded one — though even skilled managers' edge doesn't reliably survive the 13F disclosure lag. Why →
Last Close
$102.13
2026-07-24
YTD
+234.0%
99% of 52-week range
