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Of the 9 tracked institutions holding KPTI, 4 have a 3-year clone track record — 4 of them beat the S&P. Average holder's clone alpha: +4.7pt. It's a gauge of who owns the name, not just how many.
Among the 9 tracked institutional investors we monitor, KPTI (KARYOPHARM THERAPEUTICS INC) is held with a combined value of $30.17M across 5,237,472 shares. The largest holder is RA CAPITAL MANAGEMENT, L.P. with a position worth $10.68M (0.11% of their portfolio). 2 funds opened new positions in the most recent quarter. 4 funds increased their holdings. 2 funds reduced their position.
Total Institutional Value
$30.17M
Total Shares Held
5,237,472
Institutional Holders
9
Ranked by estimated dollars moved (share change × implied price). 13F data lags up to 45 days.
| # | Fund | Value↓ | Portfolio % | Change |
|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | $10.68M | 0.11% | New |
| 2 | ADAGE CAPITAL PARTNERS GP, L.L.C. | $10.06M | 0.02% | +328.7% |
| 3 | VANGUARD GROUP INC | $4.12M | 0.00% | +37.1% |
| 4 | MILLENNIUM MANAGEMENT LLC | $2.85M | 0.00% | New |
| 5 | BlackRock, Inc. | $1.36M | 0.00% | -1.1% |
| 6 | RENAISSANCE TECHNOLOGIES LLC | $587.16K | 0.00% | +75.9% |
| 7 | STATE STREET CORP | $449.73K | 0.00% | +37.0% |
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | $61.00K | 0.00% | - |
| 9 | FMR LLC | $3.70K | 0.00% | -2.1% |
As of the latest SEC 13F filings, RA CAPITAL MANAGEMENT, L.P. is the largest institutional holder of KPTI with a position worth $10.68M, representing 0.11% of their portfolio. In total, 9 institutional investors hold KPTI with a combined value of $30.17M.
In the most recent quarter, 2 funds opened a new position in KPTI. Additionally, 4 increased their holdings and 2 reduced their positions.
Institutional investors hold $30.17M worth of KPTI stock across 9 positions. The largest institutional holder is RA CAPITAL MANAGEMENT, L.P. with $10.68M in holdings.
A 13F filing is a quarterly report required by the SEC from institutional investment managers with over $100 million in assets. It discloses their holdings in U.S. equities. For KPTI, these filings reveal which major funds are accumulating or reducing positions, providing insights into institutional sentiment.
Get notified when hedge funds change their KPTI positions.
Alpha = the manager's 3-year clone return minus the S&P 500. A skilled roster is a stronger tell than a crowded one — though even skilled managers' edge doesn't reliably survive the 13F disclosure lag. Why →
Last Close
$7.41
2026-07-24
YTD
+3.1%
53% of 52-week range