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Of the 18 tracked institutions holding IONS, 11 have a 3-year clone track record — 10 of them beat the S&P. Average holder's clone alpha: +4.7pt. It's a gauge of who owns the name, not just how many.
Among the 18 tracked institutional investors we monitor, IONS (IONIS PHARMACEUTICALS INC) is held with a combined value of $5.51B across 72,443,270 shares. The largest holder is FMR LLC with a position worth $1.84B (0.10% of their portfolio). Capital Research Global Investors opened a new position in the most recent quarter. 10 funds increased their holdings. 7 funds reduced their position.
Total Institutional Value
$5.51B
Total Shares Held
72,443,270
Institutional Holders
18
% of Shares Outstanding
43.8%
of 165.26M shares · SEC 2026-04-23
Days to Cover
7.3-1.9%
17.43M shares short · FINRA 2026-06-30
Tracked 13F institutions hold 43.8% of IONS's shares outstanding. This is a floor: 13F filings arrive on a ~45-day lag and we track only a subset of institutional filers, so true institutional ownership is higher. Shares-outstanding is the latest SEC cover-page figure (as of 2026-04-23), not a live float.
Ranked by estimated dollars moved (share change × implied price). 13F data lags up to 45 days.
| # | Fund | Value↓ | Portfolio % | Change |
|---|---|---|---|---|
| 1 | FMR LLC | $1.84B | 0.10% | +2.0% |
| 2 | VANGUARD GROUP INC | $1.30B | 0.02% | -0.3% |
| 3 | BlackRock, Inc. | $784.13M | 0.01% | -1.9% |
| 4 | WELLINGTON MANAGEMENT GROUP LLP | $479.96M | 0.09% | +2.1% |
| 5 | STATE STREET CORP | $300.03M | 0.01% | +0.5% |
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | $227.17M | 0.03% | +1.3% |
| 7 | Tweedy, Browne Co LLC | $170.88M | 13.57% | -7.7% |
| 8 | BAKER BROS. ADVISORS LP | $153.76M | 0.88% | +14.3% |
| 9 | MILLENNIUM MANAGEMENT LLC | $78.96M | 0.03% | +1027.5% |
| 10 | CITADEL ADVISORS LLC | $70.77M | 0.05% | -55.8% |
| Member | Type | Date |
|---|---|---|
| Sheldon Whitehouse | Sell | Jan 20, 2016 |
As of the latest SEC 13F filings, FMR LLC is the largest institutional holder of IONS with a position worth $1.84B, representing 0.10% of their portfolio. In total, 18 institutional investors hold IONS with a combined value of $5.51B.
In the most recent quarter, 1 fund opened a new position in IONS. Additionally, 10 increased their holdings and 7 reduced their positions.
Institutional investors hold $5.51B worth of IONS stock across 18 positions. The largest institutional holder is FMR LLC with $1.84B in holdings.
A 13F filing is a quarterly report required by the SEC from institutional investment managers with over $100 million in assets. It discloses their holdings in U.S. equities. For IONS, these filings reveal which major funds are accumulating or reducing positions, providing insights into institutional sentiment.
Get notified when hedge funds change their IONS positions.
Alpha = the manager's 3-year clone return minus the S&P 500. A skilled roster is a stronger tell than a crowded one — though even skilled managers' edge doesn't reliably survive the 13F disclosure lag. Why →
Last Close
$56.55
2026-07-24
YTD
-29.0%
35% of 52-week range
