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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $8.79B
Positions: 84
Period: 2023-12-31
Filed: 2024-02-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$8.79B

Positions

84

New

5

Increased

23

Decreased

12

Sold Out

345

BAKER BROS. ADVISORS LP Q4 2023 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $8.79B across 84 positions in their Q4 2023 SEC 13F filing (period ending 2023-12-31). Top holdings include INCY ($2.27B), ONC ($1.91B), ACAD ($1.34B). The top 10 positions account for 81.0% of the portfolio. This quarter saw 5 new positions, 23 increases, 12 reductions, 345 complete exits. Notable new buys: THCH ($67.84M), CLDX ($9.82M), NGNE ($8.79M). Notable exits: SE, HRTX, TIL.

All Holdings

#StockValue↓WeightChange
1
INCYIncyte Corporation
COM
$2.27B
25.85%
+0.0%
2
ONCBeiGene, Ltd.
SPONSORED ADR
$1.91B
21.69%
-9.4%
3
ACADACADIA Pharmaceuticals Inc.
COM
$1.34B
15.27%
-
4
MDGLMadrigal Pharmaceuticals, Inc.
COM
$455.77M
5.19%
+27.5%
5
RYTMRhythm Pharmaceuticals, Inc.
COM
$294.13M
3.35%
-4.5%
6
ATIMirati Therapeutics, Inc.
COM
$242.13M
2.76%
+192.3%
7
IMCRImmunocore Holdings plc
ADS
$172.22M
1.96%
-
8
KYMRKymera Therapeutics, Inc.
COM
$152.66M
1.74%
+26.2%
9
RVMDRevolution Medicines, Inc.
COM
$147.66M
1.68%
+91.3%
10
ATIInvitae Corporation
Notes 1.5% 4/1/2028
$131.15M
1.49%
-
11
ABCLAbCellera Biologics Inc.
COM
$130.81M
1.49%
+10.3%
12
ROIVRoivant Sciences Ltd.
SHS
$85.27M
0.97%
-36.1%
13
REPLReplimune Group, Inc.
COM
$80.47M
0.92%
+108.5%
14
TRDAEntrada Therapeutics, Inc.
COM
$73.43M
0.84%
-
15
RAREUltragenyx Pharmaceutical Inc.
COM
$70.13M
0.80%
+7.3%
16
THCHCerevel Therapeutics Holdings, Inc.
COM
$67.84M
0.77%
New
17
IMTXImmatics N.V.
SHS
$61.48M
0.70%
+3.5%
18
BCRXBioCryst Pharmaceuticals, Inc.
COM
$60.66M
0.69%
-20.3%
19
ARGXargenx SE
SPONSORED ADR
$57.53M
0.65%
-
20
DNLIDenali Therapeutics Inc.
COM
$55.95M
0.64%
+13.8%
21
AKROAkero Therapeutics, Inc.
COM
$55.30M
0.63%
-
22
KODKodiak Sciences Inc.
COM
$52.62M
0.60%
-
23
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$49.28M
0.56%
-
24
XENEXenon Pharmaceuticals Inc.
COM
$45.77M
0.52%
+32.2%
25
PRLDPrelude Therapeutics Inc.
COM
$43.23M
0.49%
-
26
CERSCerus Corporation
COM
$42.07M
0.48%
+13.0%
27
NRIXNurix Therapeutics, Inc.
COM
$40.06M
0.46%
-
28
THCHAerovate Therapeutics, Inc.
COM
$38.03M
0.43%
-14.4%
29
IDYAIDEAYA Biosciences, Inc.
COM
$37.79M
0.43%
-
30
EWTXEdgewise Therapeutics, Inc.
COM
$34.05M
0.39%
+196.5%
31
SERASera Prognostics, Inc.
CLASS A COM
$32.50M
0.37%
+258.6%
32
BCYCBicycle Therapeutics plc
SPONSORED ADS
$32.37M
0.37%
+112.2%
33
IGMSIGM Biosciences, Inc.
COM
$30.67M
0.35%
+16.9%
34
BMEABiomea Fusion, Inc.
COM
$30.62M
0.35%
-
35
GLUEMonte Rosa Therapeutics, Inc.
COM
$27.78M
0.32%
-
36
VERVVerve Therapeutics, Inc.
COM
$23.58M
0.27%
+19.4%
37
KRYSKrystal Biotech, Inc.
COM
$21.08M
0.24%
-
38
IESCGracell Biotechnologies Inc.
SPONSORED ADS
$20.88M
0.24%
+108.0%
39
IMVTImmunovant, Inc.
COM
$17.91M
0.20%
-
40
TCRXTScan Therapeutics, Inc.
COM
$16.24M
0.18%
-
41
DAWNDay One Biopharmaceuticals, Inc.
COM
$14.60M
0.17%
-
42
DBV Technologies S.A.
SPONSORED ADR
$13.92M
0.16%
-
43
RLAYRelay Therapeutics, Inc.
COM
$12.77M
0.15%
-
44
THCHARS Pharmaceuticals, Inc.
COM
$11.00M
0.13%
-
45
STOKStoke Therapeutics, Inc.
COM
$10.68M
0.12%
+36.6%
46
TSVT2seventy bio, Inc.
COM
$10.66M
0.12%
-
47
INSMInsmed Incorporated
COM PAR $.01
$10.63M
0.12%
-
48
CLDXCelldex Therapeutics, Inc.
COM
$9.82M
0.11%
New
49
PRMEPrime Medicine, Inc.
COM
$9.11M
0.10%
-
50
NGNENeurogene Inc.
COM
$8.79M
0.10%
New
Showing 1-50 of 84

Position Changes

StockValueShares
THCHCerevel Therapeutics Holdings, Inc.
$67.84M1,600,000
CLDXCelldex Therapeutics, Inc.
$9.82M247,644
NGNENeurogene Inc.
$8.79M453,516
PFEPfizer Inc.
$1.01M35,000
TYRATyra Biosciences, Inc.
$146.91K10,607