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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $9.36B
Positions: 95
Period: 2024-12-31
Filed: 2025-02-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$9.36B

Positions

95

New

9

Increased

21

Decreased

4

Sold Out

367

BAKER BROS. ADVISORS LP Q4 2024 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $9.36B across 95 positions in their Q4 2024 SEC 13F filing (period ending 2024-12-31). Top holdings include INCY ($2.12B), ONC ($1.76B), ACAD ($786.81M). The top 10 positions account for 76.5% of the portfolio. This quarter saw 9 new positions, 21 increases, 4 reductions, 367 complete exits. Notable new buys: IONS ($29.54M), GRAL ($29.10M), CADL ($25.88M). Notable exits: DBVT, ALEC, TNGX.

All Holdings

#StockValue↓WeightChange
1
INCYIncyte Corporation
COM
$2.12B
22.68%
+0.0%
2
ONCBeiGene, Ltd.
SPONSORED ADR
$1.76B
18.81%
-9.8%
3
ACADACADIA Pharmaceuticals Inc.
COM
$786.81M
8.40%
-
4
MDGLMadrigal Pharmaceuticals, Inc.
COM
$609.30M
6.51%
-
5
SMMTSummit Therapeutics Inc.
COM
$435.86M
4.66%
-
6
RVMDRevolution Medicines, Inc.
COM
$347.16M
3.71%
+4.9%
7
INSMInsmed Incorporated
COM PAR $.01
$345.67M
3.69%
+13.4%
8
RYTMRhythm Pharmaceuticals, Inc.
COM
$340.60M
3.64%
-4.9%
9
KYMRKymera Therapeutics, Inc.
COM
$241.22M
2.58%
-
10
KODKodiak Sciences Inc.
COM
$172.24M
1.84%
-
11
EWTXEdgewise Therapeutics, Inc.
COM
$164.36M
1.76%
+5.4%
12
BCYCBicycle Therapeutics plc
SPONSORED ADS
$152.39M
1.63%
+15.8%
13
REPLReplimune Group, Inc.
COM
$133.76M
1.43%
-
14
ALKSAlkermes plc
SHS
$120.27M
1.28%
-
15
INSMInsmed Incorporated
Note 0.75% 6/1/2028
$92.93M
0.99%
-
16
TRDAEntrada Therapeutics, Inc.
COM
$84.13M
0.90%
-
17
ABCLAbCellera Biologics Inc.
COM
$80.65M
0.86%
-
18
DNLIDenali Therapeutics Inc.
COM
$76.05M
0.81%
-
19
NRIXNurix Therapeutics, Inc.
COM
$73.14M
0.78%
-
20
ARGXargenx SE
SPONSORED ADR
$68.82M
0.74%
-
21
RAREUltragenyx Pharmaceutical Inc.
COM
$66.31M
0.71%
-
22
KNSAKiniksa Pharmaceuticals International, plc
ORD SHS CL A
$55.75M
0.60%
-
23
IMTXImmatics N.V.
SHS
$51.73M
0.55%
+12.9%
24
CRSPCRISPR Therapeutics AG
NAMEN AKT
$51.48M
0.55%
+55.1%
25
STOKStoke Therapeutics, Inc.
COM
$51.11M
0.55%
+6.1%
26
IMCRImmunocore Holdings plc
ADS
$44.70M
0.48%
-
27
ROIVRoivant Sciences Ltd.
SHS
$44.57M
0.48%
+34.6%
28
SERASera Prognostics, Inc.
CLASS A COM
$44.24M
0.47%
-
29
IMVTImmunovant, Inc.
COM
$42.30M
0.45%
+39.4%
30
XENEXenon Pharmaceuticals Inc.
COM
$38.95M
0.42%
-
31
CELCCelcuity Inc.
COM
$35.06M
0.37%
+42.9%
32
GLUEMonte Rosa Therapeutics, Inc.
COM
$34.12M
0.36%
-
33
AKROAkero Therapeutics, Inc.
COM
$30.52M
0.33%
-
34
CERSCerus Corporation
COM
$30.00M
0.32%
-
35
IONSIonis Pharmaceuticals, Inc.
Note 1.75% 6/15/2028
$29.54M
0.32%
New
36
GRALGRAIL, Inc.
COM
$29.10M
0.31%
New
37
IDYAIDEAYA Biosciences, Inc.
COM
$27.30M
0.29%
-
38
KRYSKrystal Biotech, Inc.
COM
$26.62M
0.28%
-
39
CADLCandel Therapeutics, Inc.
COM
$25.88M
0.28%
New
40
PRAXPraxis Precision Medicines, Inc.
COM
$25.51M
0.27%
+2.6%
41
IGMSIGM Biosciences, Inc.
COM
$25.02M
0.27%
+0.0%
42
CNTACentessa Pharmaceuticals plc
SPONSORED ADS
$20.56M
0.22%
-
43
MRUSMerus N.V.
COM
$18.92M
0.20%
+50.0%
44
DYNDyne Therapeutics, Inc.
COM
$15.83M
0.17%
-
45
NGNENeurogene Inc.
COM
$15.42M
0.16%
+47.9%
46
XNCRXencor, Inc.
COM
$15.41M
0.16%
-
47
BCAXBicara Therapeutics Inc.
COM
$14.52M
0.16%
-
48
PRLDPrelude Therapeutics Inc.
COM
$12.91M
0.14%
-
49
IONSIonis Pharmaceuticals, Inc.
COM
$12.51M
0.13%
+60.2%
50
ALMSAlumis Inc.
COM
$12.28M
0.13%
-
Showing 1-50 of 95

Position Changes

StockValueShares
IONSIonis Pharmaceuticals, Inc.
$29.54M30,000,000
GRALGRAIL, Inc.
$29.10M1,630,125
CADLCandel Therapeutics, Inc.
$25.88M2,981,983
VIRVir Biotechnology, Inc.
$7.96M1,084,539
BNTXBioNTech SE
$5.13M45,031
IRONDisc Medicine, Inc.
$4.88M77,050
DBVTDBV Technologies S.A.
$4.52M1,461,425
RCKTRocket Pharmaceuticals, Inc.
$1.22M97,079
PTCTPTC Therapeutics, Inc.
$920.86K20,400