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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $7.97B
Positions: 87
Period: 2024-03-31
Filed: 2024-05-15
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$7.97B

Positions

87

New

11

Increased

17

Decreased

7

Sold Out

353

BAKER BROS. ADVISORS LP Q1 2024 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $7.97B across 87 positions in their Q1 2024 SEC 13F filing (period ending 2024-03-31). Top holdings include INCY ($2.06B), ONC ($1.65B), ACAD ($792.57M). The top 10 positions account for 77.1% of the portfolio. This quarter saw 11 new positions, 17 increases, 7 reductions, 353 complete exits. Notable new buys: NMRA ($8.72M), DYN ($8.09M), PRAX ($8.03M). Notable exits: ATI, ATI, ATI.

All Holdings

#StockValue↓WeightChange
1
INCYIncyte Corporation
COM
$2.06B
25.86%
+0.0%
2
ONCBeiGene, Ltd.
SPONSORED ADR
$1.65B
20.73%
-
3
ACADACADIA Pharmaceuticals Inc.
COM
$792.57M
9.94%
-
4
MDGLMadrigal Pharmaceuticals, Inc.
COM
$526.01M
6.60%
-
5
RYTMRhythm Pharmaceuticals, Inc.
COM
$277.24M
3.48%
-
6
RVMDRevolution Medicines, Inc.
COM
$243.31M
3.05%
+46.6%
7
KYMRKymera Therapeutics, Inc.
COM
$241.04M
3.02%
-
8
ABCLAbCellera Biologics Inc.
COM
$124.69M
1.56%
+20.1%
9
BCYCBicycle Therapeutics plc
SPONSORED ADS
$123.08M
1.54%
+176.1%
10
EWTXEdgewise Therapeutics, Inc.
COM
$106.52M
1.34%
+87.6%
11
IMCRImmunocore Holdings plc
ADS
$98.50M
1.24%
-39.9%
12
KODKodiak Sciences Inc.
COM
$91.05M
1.14%
-
13
ROIVRoivant Sciences Ltd.
SHS
$78.14M
0.98%
-2.4%
14
REPLReplimune Group, Inc.
COM
$77.99M
0.98%
-
15
DNLIDenali Therapeutics Inc.
COM
$76.57M
0.96%
+43.1%
16
TRDAEntrada Therapeutics, Inc.
COM
$68.95M
0.86%
-
17
AKROAkero Therapeutics, Inc.
COM
$68.54M
0.86%
+14.6%
18
RAREUltragenyx Pharmaceutical Inc.
COM
$68.47M
0.86%
-
19
IMTXImmatics N.V.
SHS
$67.72M
0.85%
+10.4%
20
THCHCerevel Therapeutics Holdings, Inc.
COM
$67.63M
0.85%
-
21
ARGXargenx SE
SPONSORED ADR
$59.54M
0.75%
-
22
NRIXNurix Therapeutics, Inc.
COM
$57.07M
0.72%
-
23
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$55.43M
0.70%
-
24
BCRXBioCryst Pharmaceuticals, Inc.
COM
$51.44M
0.65%
-
25
THCHAerovate Therapeutics, Inc.
COM
$49.69M
0.62%
-
26
SERASera Prognostics, Inc.
CLASS A COM
$49.45M
0.62%
-
27
PRLDPrelude Therapeutics Inc.
COM
$47.99M
0.60%
-
28
IDYAIDEAYA Biosciences, Inc.
COM
$46.61M
0.58%
-
29
STOKStoke Therapeutics, Inc.
COM
$45.47M
0.57%
+65.9%
30
XENEXenon Pharmaceuticals Inc.
COM
$42.78M
0.54%
-
31
IGMSIGM Biosciences, Inc.
COM
$39.45M
0.49%
+10.8%
32
CERSCerus Corporation
COM
$36.81M
0.46%
-
33
GLUEMonte Rosa Therapeutics, Inc.
COM
$34.66M
0.43%
-
34
CELCCelcuity Inc.
COM
$33.53M
0.42%
+189.9%
35
BMEABiomea Fusion, Inc.
COM
$31.53M
0.40%
-
36
KRYSKrystal Biotech, Inc.
COM
$30.24M
0.38%
-
37
SANASana Biotechnology, Inc.
COM
$23.81M
0.30%
+19.0%
38
NGNENeurogene Inc.
COM
$23.21M
0.29%
+0.6%
39
VERVVerve Therapeutics, Inc.
COM
$22.46M
0.28%
-
40
TCRXTScan Therapeutics, Inc.
COM
$22.11M
0.28%
-
41
ADAPAdaptimmune Therapeutics plc
SPONSORED ADR
$17.04M
0.21%
-1.7%
42
IMVTImmunovant, Inc.
COM
$13.73M
0.17%
-
43
TSVT2seventy bio, Inc.
COMMON STOCK
$13.36M
0.17%
-
44
FATEFate Therapeutics, Inc.
COM
$13.35M
0.17%
+0.0%
45
XNCRXencor, Inc.
COM
$12.07M
0.15%
+122.2%
46
TSHATaysha Gene Therapies, Inc.
COM SHS
$11.49M
0.14%
-
47
DBV Technologies S.A.
SPONSORED ADR
$10.95M
0.14%
-
48
CLDXCelldex Therapeutics, Inc.
COM
$10.39M
0.13%
-
49
RLAYRelay Therapeutics, Inc.
COM
$9.63M
0.12%
-
50
INSMInsmed Incorporated
COM PAR $.01
$9.31M
0.12%
-
Showing 1-50 of 87

Position Changes

StockValueShares
NMRANeumora Therapeutics, Inc.
$8.72M633,851
DYNDyne Therapeutics, Inc.
$8.09M285,000
PRAXPraxis Precision Medicines, Inc.
$8.03M131,533
Alpine Immune Sciences, Inc.
$3.23M81,578
FDMT4D Molecular Therapeutics, Inc.
$3.19M100,000
NAMSNewAmsterdam Pharma Company N.V.
$2.29M96,827
VTVTvTv Therapeutics, Inc.
$2.29M97,314
ELVNEnliven Therapeutics, Inc.
$2.02M114,833
GBIOGeneration Bio Co.
$1.51M371,219
OLOMural Oncology plc
$1.09M222,503
ACRVAcrivon Therapeutics, Inc.
$378.13K52,885