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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $17.28B
Positions: 107
Period: 2023-06-30
Filed: 2023-08-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$17.28B

Positions

107

New

8

Increased

22

Decreased

11

Sold Out

309

BAKER BROS. ADVISORS LP Q2 2023 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $17.28B across 107 positions in their Q2 2023 SEC 13F filing (period ending 2023-06-30). Top holdings include SE ($8.57B), INCY ($2.25B), ONC ($2.08B). The top 10 positions account for 87.6% of the portfolio. This quarter saw 8 new positions, 22 increases, 11 reductions, 309 complete exits. Notable new buys: ATI ($135.00M), DAWN ($11.94M), COGT ($11.60M). Notable exits: VSTM, MEDG, LPTX.

All Holdings

#StockValue↓WeightChange
1
SESeagen Inc.
COM
$8.57B
49.63%
-5.0%
2
INCYIncyte Corporation
COM
$2.25B
13.03%
+0.0%
3
ONCBeiGene, Ltd.
SPONSORED ADR
$2.08B
12.04%
-
4
ACADACADIA Pharmaceuticals Inc.
COM
$1.03B
5.94%
+2.2%
5
MDGLMadrigal Pharmaceuticals, Inc.
COM
$356.92M
2.07%
-
6
BMRNBioMarin Pharmaceutical Inc.
COM
$330.27M
1.91%
-
7
IMCRImmunocore Holdings plc
ADS
$151.14M
0.87%
-
8
ATIInvitae Corporation
Note 1.5% 4/1/2028
$135.00M
0.78%
New
9
KODKodiak Sciences Inc.
COM
$119.44M
0.69%
-
10
AKROAkero Therapeutics, Inc.
COM
$110.58M
0.64%
-
11
ARGXargenx SE
SPONSORED ADR
$109.19M
0.63%
-
12
RYTMRhythm Pharmaceuticals, Inc.
COM
$107.16M
0.62%
-
13
REPLReplimune Group, Inc.
COM
$106.31M
0.62%
-
14
ABCLAbCellera Biologics Inc.
COM
$106.27M
0.62%
+57.4%
15
KYMRKymera Therapeutics, Inc.
COM
$100.59M
0.58%
+51.9%
16
ROIVRoivant Sciences Ltd.
SHS
$95.04M
0.55%
+97.4%
17
BCRXBioCryst Pharmaceuticals, Inc.
COM
$89.48M
0.52%
-
18
SWTXSpringWorks Therapeutics, Inc.
COM
$78.66M
0.46%
+8.9%
19
TRDAEntrada Therapeutics, Inc.
COM
$73.67M
0.43%
-
20
RVMDRevolution Medicines, Inc.
COM
$72.00M
0.42%
-
21
IMTXImmatics N.V.
SHS
$65.10M
0.38%
+8.7%
22
THCHChinook Therapeutics, Inc.
COM
$55.91M
0.32%
-
23
ATIMirati Therapeutics, Inc.
COM
$50.94M
0.29%
-
24
THCHDICE Therapeutics, Inc.
COM
$48.12M
0.28%
-
25
BMEABiomea Fusion, Inc.
COM
$46.29M
0.27%
-
26
PRLDPrelude Therapeutics Inc.
COM
$45.56M
0.26%
-
27
DNLIDenali Therapeutics Inc.
COM
$42.95M
0.25%
+33.7%
28
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$39.56M
0.23%
+0.4%
29
CERSCerus Corporation
COM
$39.53M
0.23%
-
30
NRIXNurix Therapeutics, Inc.
COM
$38.78M
0.22%
-
31
RAREUltragenyx Pharmaceutical Inc.
COM
$36.12M
0.21%
+66.3%
32
THCHAerovate Therapeutics, Inc.
COM
$33.67M
0.19%
-
33
IGMSIGM Biosciences, Inc.
COM
$29.14M
0.17%
+0.0%
34
XENEXenon Pharmaceuticals Inc.
COM
$28.94M
0.17%
-
35
ImmunoGen, Inc.
COM
$28.68M
0.17%
+0.0%
36
DBV Technologies S.A.
SPONSORED ADR
$27.77M
0.16%
-
37
VERVVerve Therapeutics, Inc.
COM
$26.56M
0.15%
-
38
TSVT2seventy bio, Inc.
COMMON STOCK
$25.27M
0.15%
-
39
IDYAIDEAYA Biosciences, Inc.
COM
$24.96M
0.14%
+27.5%
40
STOKStoke Therapeutics, Inc.
COM
$22.64M
0.13%
+0.7%
41
BCYCBicycle Therapeutics plc
SPONSORED ADS
$21.53M
0.12%
-
42
GLUEMonte Rosa Therapeutics, Inc.
COM
$20.71M
0.12%
+706.2%
43
CABACabaletta Bio, Inc.
COM
$20.58M
0.12%
+18.6%
44
KRYSKrystal Biotech, Inc.
COM
$19.95M
0.12%
-43.9%
45
SMMTSummit Therapeutics Inc.
COM
$15.82M
0.09%
-
46
ANABAnaptysBio, Inc.
COM
$15.78M
0.09%
-
47
PRMEPrime Medicine, Inc.
COM
$15.07M
0.09%
-
48
PACBPacific Biosciences of California, Inc.
COM
$15.00M
0.09%
-
49
RLAYRelay Therapeutics, Inc.
COM
$14.57M
0.08%
+308.5%
50
THCHARS Pharmaceuticals, Inc.
COM
$13.44M
0.08%
-
Showing 1-50 of 107

Position Changes

StockValueShares
ATIInvitae Corporation
$135.00M300,000,000
DAWNDay One Biopharmaceuticals, Inc.
$11.94M1,000,000
COGTCogent Biosciences, Inc.
$11.60M979,600
VSTMVerastem, Inc.
$9.94M1,336,485
IESCGracell Biotechnologies Inc.
$3.81M1,000,000
LPTXLeap Therapeutics, Inc.
$3.67M1,172,175
MEDGTalis Biomedical Corporation
$3.66M7,624,835
Perspective Therapeutics, Inc.
$1.55M2,319,286