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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $22.77B
Positions: 122
Period: 2021-09-30
Filed: 2021-11-15
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$22.77B

Positions

122

New

11

Increased

22

Decreased

7

Sold Out

249

BAKER BROS. ADVISORS LP Q3 2021 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $22.77B across 122 positions in their Q3 2021 SEC 13F filing (period ending 2021-09-30). Top holdings include SE ($8.03B), ONC ($4.24B), INCY ($2.20B). The top 10 positions account for 82.7% of the portfolio. This quarter saw 11 new positions, 22 increases, 7 reductions, 249 complete exits. Notable new buys: THCH ($19.27M), SRZN ($17.70M), TCRX ($11.88M). Notable exits: APLS, ASMB, Chiasma, Inc..

All Holdings

#StockValue↓WeightChange
1
SESeagen Inc.
COM
$8.03B
35.26%
-
2
ONCBeiGene, Ltd.
SPONSORED ADR
$4.24B
18.60%
-
3
INCYIncyte Corporation
COM
$2.20B
9.67%
+0.0%
4
KODKodiak Sciences Inc.
COM
$1.41B
6.19%
+3.8%
5
ASNDAscendis Pharma A/S
SPONSORED ADR
$723.89M
3.18%
+28.3%
6
ACADACADIA Pharmaceuticals Inc.
COM
$696.14M
3.06%
-
7
BMRNBioMarin Pharmaceutical Inc.
COM
$588.99M
2.59%
+0.4%
8
ARGXargenx SE
SPONSORED ADR
$338.11M
1.48%
-
9
PRLDPrelude Therapeutics Inc.
COM
$316.37M
1.39%
-
10
Invitae Corporation
COM
$280.70M
1.23%
-3.7%
11
ATIMirati Therapeutics, Inc.
COM
$249.41M
1.10%
-
12
ABCLAbCellera Biologics Inc.
COM
$209.42M
0.92%
-
13
IGMSIGM Biosciences, Inc.
COM
$207.54M
0.91%
-
14
BCRXBioCryst Pharmaceuticals, Inc.
COM
$182.65M
0.80%
-
15
KYMRKymera Therapeutics, Inc.
COM
$140.08M
0.62%
+21.7%
16
PACBPacific Biosciences of California, Inc.
COM
$139.12M
0.61%
+70.1%
17
MDGLMadrigal Pharmaceuticals, Inc.
COM
$119.62M
0.53%
-
18
LEGNLegend Biotech Corporation
SPONSORED ADS
$119.52M
0.52%
+42.0%
19
AMRNAmarin Corporation plc
SPONSORED ADR
$111.47M
0.49%
-17.4%
20
IMCRImmunocore Holdings plc
ADS
$93.44M
0.41%
-
21
HRTXHeron Therapeutics, Inc.
COM
$86.93M
0.38%
-
22
CERSCerus Corporation
COM
$83.51M
0.37%
-
23
THCHGlobal Blood Therapeutics, Inc.
COM
$81.98M
0.36%
-
24
ALLKAllakos Inc.
COM
$74.43M
0.33%
-
25
NRIXNurix Therapeutics, Inc.
COM
$73.52M
0.32%
-
26
DBV Technologies S.A.
SPONSORED ADR
$71.61M
0.31%
-
27
TILInstil Bio, Inc.
COM
$69.60M
0.31%
-
28
VERVVerve Therapeutics, Inc.
COM
$66.58M
0.29%
-
29
VSTMVerastem, Inc.
COM
$66.19M
0.29%
-
30
THCHHorizon Therapeutics Public Ltd Co
SHS
$65.63M
0.29%
-
31
NBIXNeurocrine Biosciences, Inc.
COM
$64.93M
0.29%
-
32
INSMInsmed Incorporated
COM PAR $.01
$59.38M
0.26%
-
33
IMTXImmatics N.V.
SHS
$57.51M
0.25%
+3.3%
34
APLSApellis Pharmaceuticals, Inc.
Note 3.5% 9/15/2026
$57.26M
0.25%
+211.7%
35
ADAPAdaptimmune Therapeutics plc
SPONSORED ADR
$50.83M
0.22%
-
36
RYTMRhythm Pharmaceuticals, Inc.
COM
$50.45M
0.22%
-
37
ZYMEZymeworks Inc.
COM
$49.61M
0.22%
-
38
TVTXTravere Therapeutics, Inc.
COM
$49.46M
0.22%
+991.3%
39
BLUEbluebird bio, Inc.
COM
$47.77M
0.21%
+1001.3%
40
MEDGTalis Biomedical Corporation
COM
$47.34M
0.21%
-
41
THCHForma Therapeutics Holdings, Inc.
SHS
$46.96M
0.21%
-
42
MRUSMerus N.V.
COM
$44.82M
0.20%
-
43
INSMInsmed Incorporated
Note 0.75% 6/1/2028
$43.84M
0.19%
-
44
SRPTSarepta Therapeutics, Inc.
DBCV 1.5% 11/15/2024
$43.17M
0.19%
-
45
RAREUltragenyx Pharmaceutical Inc.
COM
$40.08M
0.18%
-
46
ALKSAlkermes plc
SHS
$37.88M
0.17%
-
47
FLGTFulgent Genetics, Inc.
COM
$36.07M
0.16%
-
48
THCHAerovate Therapeutics, Inc.
COM
$34.66M
0.15%
+15.7%
49
ALGSAligos Therapeutics, Inc.
COM
$32.20M
0.14%
+29.0%
50
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$31.89M
0.14%
-
Showing 1-50 of 122

Position Changes

StockValueShares
THCHDICE Therapeutics, Inc.
$19.27M588,235
SRZNSurrozen, Inc.
$17.70M2,500,000
TCRXTscan Therapeutics, Inc.
$11.88M1,425,000
TNGXTango Therapeutics, Inc.
$9.70M750,000
Amryt Pharma plc
$6.24M518,380
KURAKura Oncology, Inc.
$5.70M304,158
ATYRaTyr Pharma, Inc.
$5.67M625,000
VINCVincerx Pharma, Inc.
$3.90M241,379
SERASera Prognostics, Inc.
$2.24M201,562
SNDXSyndax Pharmaceuticals, Inc.
$2.12M110,729
SRZNSurrozen, Inc.
$950.00K833,333