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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $22.77B
Positions: 120
Period: 2021-06-30
Filed: 2021-08-16
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$22.77B

Positions

120

New

9

Increased

17

Decreased

10

Sold Out

240

BAKER BROS. ADVISORS LP Q2 2021 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $22.77B across 120 positions in their Q2 2021 SEC 13F filing (period ending 2021-06-30). Top holdings include SE ($7.47B), ONC ($4.00B), INCY ($2.69B). The top 10 positions account for 81.6% of the portfolio. This quarter saw 9 new positions, 17 increases, 10 reductions, 240 complete exits. Notable new buys: VERV ($85.35M), INSM ($44.06M), THCH ($32.61M). Notable exits: Alexion Pharmaceuticals, Inc., Idera Pharmaceuticals, Inc., ChemoCentryx, Inc..

All Holdings

#StockValue↓WeightChange
1
SESeagen Inc.
COM
$7.47B
32.79%
+0.0%
2
ONCBeiGene, Ltd.
SPONSORED ADR
$4.00B
17.59%
-
3
INCYIncyte Corporation
COM
$2.69B
11.83%
+0.1%
4
KODKodiak Sciences Inc.
COM
$1.31B
5.77%
+1.9%
5
ACADACADIA Pharmaceuticals Inc.
COM
$1.02B
4.49%
-
6
BMRNBioMarin Pharmaceutical Inc.
COM
$633.25M
2.78%
-
7
ASNDAscendis Pharma A/S
SPONSORED ADR
$465.72M
2.05%
-
8
Invitae Corporation
COM
$345.68M
1.52%
-34.9%
9
ARGXargenx SE
SPONSORED ADR
$337.06M
1.48%
-
10
PRLDPrelude Therapeutics Incorporated
COM
$289.85M
1.27%
-
11
IGMSIGM Biosciences, Inc.
COM
$262.59M
1.15%
-
12
ABCLAbCellera Biologics Inc.
COM
$229.90M
1.01%
-
13
ATIMirati Therapeutics, Inc.
COM
$227.72M
1.00%
-
14
BCRXBioCryst Pharmaceuticals, Inc.
COM
$200.96M
0.88%
-
15
MDGLMadrigal Pharmaceuticals, Inc.
COM
$146.04M
0.64%
-
16
APLSApellis Pharmaceuticals, Inc.
COM
$143.59M
0.63%
+35.7%
17
HRTXHeron Therapeutics, Inc.
COM
$126.20M
0.55%
+35.6%
18
AMRNAmarin Corporation plc
SPONSORED ADR
$115.87M
0.51%
-
19
THCHGlobal Blood Therapeutics, Inc.
COM
$112.67M
0.49%
-
20
PACBPacific Biosciences of California, Inc.
COM
$111.97M
0.49%
-
21
IMCRImmunocore Holdings plc
ADS
$98.44M
0.43%
-
22
KYMRKymera Therapeutics, Inc.
COM
$95.02M
0.42%
-
23
VSTMVerastem, Inc.
COM
$87.47M
0.38%
+26.3%
24
VERVVerve Therapeutics, Inc.
COM
$85.35M
0.37%
New
25
MEDGTalis Biomedical Corporation
COM
$83.55M
0.37%
-
26
CERSCerus Corporation
COM
$81.05M
0.36%
-
27
DBV Technologies S.A.
SPONSORED ADR
$79.79M
0.35%
-
28
RYTMRhythm Pharmaceuticals, Inc.
COM
$75.64M
0.33%
+11.0%
29
TILInstil Bio, Inc.
COM
$75.23M
0.33%
-
30
LEGNLegend Biotech Corporation
SPONSORED ADS
$68.33M
0.30%
+1339.6%
31
NBIXNeurocrine Biosciences, Inc.
COM
$65.88M
0.29%
-
32
NRIXNurix Therapeutics, Inc.
COM
$65.11M
0.29%
-
33
INSMInsmed Incorporated
COM PAR $.01
$61.36M
0.27%
-
34
ALLKAllakos Inc.
COM
$60.02M
0.26%
-
35
ZYMEZymeworks Inc.
COM
$59.27M
0.26%
-
36
THCHHorizon Therapeutics Public Ltd Co
SHS
$56.10M
0.25%
-
37
THCHForma Therapeutics Holdings, Inc.
SHS
$50.40M
0.22%
-
38
IMTXImmatics N.V.
SHS
$49.73M
0.22%
+7.3%
39
INSMInsmed Incorporated
Note 0.75% 6/1/2028
$44.06M
0.19%
New
40
MRUSMerus N.V.
COM
$42.93M
0.19%
-
41
RAREUltragenyx Pharmaceutical Inc.
COM
$42.38M
0.19%
-
42
ADAPAdaptimmune Therapeutics plc
SPONSORED ADR
$41.88M
0.18%
-
43
KRYSKrystal Biotech, Inc.
COM
$41.33M
0.18%
-20.1%
44
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$39.00M
0.17%
-
45
SRPTSarepta Therapeutics, Inc.
DBCV 1.5% 11/15/2024
$38.48M
0.17%
+218.0%
46
FLGTFulgent Genetics, Inc.
COM
$36.99M
0.16%
-
47
AXSMAxsome Therapeutics, Inc.
COM
$36.37M
0.16%
-14.2%
48
THCHNeoleukin Therapeutics, Inc.
COM
$35.27M
0.15%
-
49
BCABBioAtla, Inc.
COM
$34.96M
0.15%
-
50
ADCTADC Therapeutics SA
SHS
$34.53M
0.15%
-
Showing 1-50 of 120

Position Changes

StockValueShares
VERVVerve Therapeutics, Inc.
$85.35M1,416,530
INSMInsmed Incorporated
$44.06M40,000,000
THCHAerovate Therapeutics, Inc.
$32.61M1,428,571
APLSApellis Pharmaceuticals, Inc.
$27.79M15,000,000
Tricida, Inc.
$27.33M75,000,000
THCHCyteir Therapeutics, Inc.
$17.39M812,640
CNTACentessa Pharmaceuticals plc
$8.88M400,000
BMEABiomea Fusion, Inc.
$4.59M294,117
RLMDRelmada Therapeutics, Inc.
$2.45M76,600