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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $14.70B
Positions: 109
Period: 2019-09-30
Filed: 2019-11-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$14.70B

Positions

109

New

8

Increased

15

Decreased

6

Sold Out

172

BAKER BROS. ADVISORS LP Q3 2019 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $14.70B across 109 positions in their Q3 2019 SEC 13F filing (period ending 2019-09-30). Top holdings include SE ($4.27B), INCY ($2.37B), ACAD ($1.47B). The top 10 positions account for 85.9% of the portfolio. This quarter saw 8 new positions, 15 increases, 6 reductions, 172 complete exits. Notable new buys: IGMS ($55.81M), THCH ($32.22M), ALLK ($26.71M). Notable exits: Aquinox Pharmaceuticals, Inc., ARRY, THCH.

All Holdings

#StockValue↓WeightChange
1
SESeattle Genetics, Inc.
COM
$4.27B
29.08%
-
2
INCYIncyte Corporation
COM
$2.37B
16.15%
+0.0%
3
ACADACADIA Pharmaceuticals Inc.
COM
$1.47B
10.00%
+4.0%
4
ONCBeiGene, Ltd.
SPONSORED ADR
$1.44B
9.81%
-
5
Alexion Pharmaceuticals, Inc.
COM
$808.79M
5.50%
-
6
AMRNAmarin Corporation plc
SPONSORED ADR
$629.81M
4.28%
-
7
THCHGenomic Health, Inc.
COM
$626.97M
4.27%
-0.2%
8
BMRNBioMarin Pharmaceutical Inc.
COM
$511.52M
3.48%
-
9
ASNDAscendis Pharma A/S
SPONSORED ADR
$326.55M
2.22%
-
10
Invitae Corporation
COM
$169.44M
1.15%
+125.3%
11
KODKodiak Sciences Inc.
COM
$131.51M
0.89%
+0.0%
12
NBIXNeurocrine Biosciences, Inc.
COM
$127.53M
0.87%
-
13
ARGXargenx SE
SPONSORED ADR
$116.19M
0.79%
-
14
HRTXHeron Therapeutics, Inc.
COM
$111.33M
0.76%
-
15
ATIMirati Therapeutics, Inc.
COM
$101.85M
0.69%
-48.0%
16
MDGLMadrigal Pharmaceuticals, Inc.
COM
$100.81M
0.69%
-
17
MyoKardia, Inc.
COM
$79.12M
0.54%
+49.3%
18
PARSpark Therapeutics, Inc.
COM
$72.92M
0.50%
-
19
Tricida, Inc.
COM
$60.81M
0.41%
-
20
RYTMRhythm Pharmaceuticals, Inc.
COM
$58.47M
0.40%
-
21
IGMSIGM Biosciences, Inc.
COM
$55.81M
0.38%
New
22
MIRARa Pharmaceuticals, Inc.
COM
$55.47M
0.38%
+30.2%
23
CERSCerus Corporation
COM
$55.42M
0.38%
-
24
DBV Technologies S.A.
SPONSORED ADR
$47.38M
0.32%
-
25
Principia Biopharma Inc.
COM
$46.71M
0.32%
-7.5%
26
Atreca, Inc.
CL A Common
$43.24M
0.29%
-
27
GW Pharmaceuticals plc
ADS
$42.66M
0.29%
-
28
ZYMEZymeworks Inc.
COM
$42.37M
0.29%
-
29
THCHAudentes Therapeutics, Inc.
COM
$42.32M
0.29%
-
30
NBIXNeurocrine Biosciences, Inc.
NOTE 2.25% 5/15/2024
$42.11M
0.29%
-
31
INSMInsmed Incorporated
COM PAR $.01
$39.33M
0.27%
-9.4%
32
BCRXBioCryst Pharmaceuticals, Inc.
COM
$36.46M
0.25%
-11.5%
33
APTVAdaptive Biotechnologies Corporation
COM
$36.01M
0.24%
-
34
KRYSKrystal Biotech, Inc.
COM
$35.93M
0.24%
-
35
THCHNeoleukin Therapeutics, Inc.
COM
$32.22M
0.22%
New
36
THCHCymaBay Therapeutics, Inc.
COM
$29.22M
0.20%
-
37
ALLKAllakos Inc.
COM
$26.71M
0.18%
New
38
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$23.82M
0.16%
-
39
MRUSMerus N.V.
COM
$20.67M
0.14%
-
40
QUREuniQure N.V.
SHS
$20.38M
0.14%
-
41
URGNUroGen Pharma Ltd.
COM
$17.82M
0.12%
New
42
AXSMAxsome Therapeutics, Inc.
COM
$15.63M
0.11%
-
43
BMRNBioMarin Pharmaceutical Inc.
NOTE 0.599% 8/1/2024
$14.72M
0.10%
-
44
XNCRXencor, Inc.
COM
$14.44M
0.10%
-
45
THCHAimmune Therapeutics, Inc.
COM
$14.11M
0.10%
-
46
PTGXProtagonist Therapeutics, Inc.
COM
$14.10M
0.10%
+18.0%
47
La Jolla Pharmaceutical Company
COM PAR $.0001 2
$13.72M
0.09%
-
48
Idera Pharmaceuticals, Inc.
COM PAR
$13.32M
0.09%
+0.1%
49
THCHAeglea BioTherapeutics, Inc.
COM
$13.18M
0.09%
-
50
ALKSAlkermes plc
SHS
$12.19M
0.08%
+56.3%
Showing 1-50 of 109

Position Changes

StockValueShares
IGMSIGM Biosciences, Inc.
$55.81M3,144,000
THCHNeoleukin Therapeutics, Inc.
$32.22M11,305,679
ALLKAllakos Inc.
$26.71M339,690
URGNUroGen Pharma Ltd.
$17.82M747,751
MIRMMirum Pharmaceuticals, Inc.
$3.35M333,333
MTNBMatinas BioPharma Holdings, Inc.
$1.25M1,984,965
LPTXLeap Therapeutics, Inc.
$1.15M978,454
EVFMEvofem Biosciences, Inc.
$514.00K102,048