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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $14.71B
Positions: 103
Period: 2019-06-30
Filed: 2019-08-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$14.71B

Positions

103

New

11

Increased

15

Decreased

17

Sold Out

170

BAKER BROS. ADVISORS LP Q2 2019 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $14.71B across 103 positions in their Q2 2019 SEC 13F filing (period ending 2019-06-30). Top holdings include SE ($3.46B), INCY ($2.72B), ONC ($1.46B). The top 10 positions account for 84.4% of the portfolio. This quarter saw 11 new positions, 15 increases, 17 reductions, 170 complete exits. Notable new buys: Atreca, Inc. ($66.56M), APTV ($56.29M), MIST ($7.24M). Notable exits: Clementia Pharmaceuticals Inc., ContraFect Corporation, MGNX.

All Holdings

#StockValue↓WeightChange
1
SESeattle Genetics, Inc.
COM
$3.46B
23.55%
-1.9%
2
INCYIncyte Corporation
COM
$2.72B
18.46%
-6.7%
3
ONCBeiGene, Ltd.
SPONSORED ADR
$1.46B
9.92%
-1.5%
4
Alexion Pharmaceuticals, Inc.
COM
$1.08B
7.35%
-3.5%
5
ACADACADIA Pharmaceuticals Inc.
COM
$1.05B
7.14%
-1.1%
6
AMRNAmarin Corporation plc
SPONSORED ADR
$805.54M
5.47%
-3.9%
7
BMRNBioMarin Pharmaceutical Inc.
COM
$650.02M
4.42%
-
8
THCHGenomic Health, Inc.
COM
$538.71M
3.66%
-9.2%
9
ASNDAscendis Pharma A/S
SPONSORED ADR
$390.39M
2.65%
-
10
ATIMirati Therapeutics, Inc.
COM
$258.89M
1.76%
-
11
ARGXargenx SE
SPONSORED ADR
$144.35M
0.98%
-
12
ARRYArray BioPharma Inc.
COM
$131.97M
0.90%
-25.9%
13
MDGLMadrigal Pharmaceuticals, Inc.
COM
$122.55M
0.83%
-
14
NBIXNeurocrine Biosciences, Inc.
COM
$119.49M
0.81%
+28.8%
15
HRTXHeron Therapeutics, Inc.
COM
$111.88M
0.76%
+19.9%
16
KODKodiak Sciences, Inc.
COM
$107.00M
0.73%
-
17
Invitae Corporation
COM
$91.71M
0.62%
-
18
Tricida, Inc.
COM
$77.73M
0.53%
+9.2%
19
PARSpark Therapeutics, Inc.
COM
$76.98M
0.52%
-
20
Atreca, Inc.
CL A Common
$66.56M
0.45%
New
21
GW Pharmaceuticals plc
ADS
$63.93M
0.43%
-13.4%
22
INSMInsmed Incorporated
COM PAR $.01
$63.03M
0.43%
+18.5%
23
CERSCerus Corporation
COM
$60.41M
0.41%
-
24
RYTMRhythm Pharmaceuticals, Inc.
COM
$59.58M
0.40%
-
25
Principia Biopharma Inc.
COM
$59.34M
0.40%
-
26
THCHAudentes Therapeutics, Inc.
COM
$57.03M
0.39%
-12.2%
27
APTVAdaptive Biotechnologies Corporation
COM
$56.29M
0.38%
New
28
BCRXBioCryst Pharmaceuticals, Inc.
COM
$54.51M
0.37%
-4.9%
29
MIRARa Pharmaceuticals, Inc.
COM
$54.18M
0.37%
+118.9%
30
MyoKardia, Inc.
COM
$50.96M
0.35%
-
31
DBV Technologies S.A.
SPONSORED ADR
$45.29M
0.31%
-
32
KRYSKrystal Biotech, Inc.
COM
$41.67M
0.28%
+31.9%
33
THCHCymaBay Therapeutics, Inc.
COM
$40.87M
0.28%
-
34
NBIXNeurocrine Biosciences, Inc.
NOTE 2.25% 5/15/2024
$40.54M
0.28%
-42.2%
35
QUREuniQure N.V.
SHS
$40.46M
0.27%
-14.4%
36
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$37.91M
0.26%
-6.7%
37
ZYMEZymeworks Inc.
COM
$37.59M
0.26%
-
38
Aquinox Pharmaceuticals, Inc.
COM
$25.80M
0.18%
-
39
AXSMAxsome Therapeutics, Inc.
COM
$19.89M
0.14%
-35.6%
40
XNCRXencor, Inc.
COM
$17.52M
0.12%
-
41
MRUSMerus N.V.
COM
$16.99M
0.12%
-
42
BMRNBioMarin Pharmaceutical Inc.
NOTE 0.599% 8/1/2024
$15.57M
0.11%
-
43
THCHAcorda Therapeutics, Inc.
COM
$15.43M
0.10%
+588.4%
44
La Jolla Pharmaceutical Company
COM PAR $.0001 2
$14.42M
0.10%
+208.6%
45
THCHAimmune Therapeutics, Inc.
COM
$14.03M
0.10%
-
46
Idera Pharmaceuticals, Inc.
COM PAR
$12.30M
0.08%
-4.8%
47
PTGXProtagonist Therapeutics, Inc.
COM
$12.05M
0.08%
+146.4%
48
MRKRMarker Therapeutics, Inc.
COM
$11.88M
0.08%
-
49
THCHAeglea BioTherapeutics, Inc.
COM
$11.74M
0.08%
-
50
ASMBAssembly Biosciences, Inc.
COM
$10.84M
0.07%
+440.6%
Showing 1-50 of 103

Position Changes

StockValueShares
Atreca, Inc.
$66.56M3,532,760
APTVAdaptive Biotechnologies Corporation
$56.29M1,165,411
MISTMilestone Pharmaceuticals Inc.
$7.24M266,667
HOOKHOOKIPA Pharma Inc.
$6.01M892,857
NGM Biopharmaceuticals, Inc.
$3.66M250,000
XBITXBiotech Inc.
$2.88M380,442
CYCNCyclerion Therapeutics, Inc.
$2.32M202,581
NXTCNextCure, Inc.
$2.25M150,000
IDYAIDEAYA Biosciences, Inc.
$1.99M200,000
THCHAileron Therapeutics, Inc.
$1.47M2,040,000
Dova Pharmaceuticals, Inc.
$1.40M99,405