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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $15.18B
Positions: 97
Period: 2018-09-30
Filed: 2018-11-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$15.18B

Positions

97

New

6

Increased

15

Decreased

22

Sold Out

156

BAKER BROS. ADVISORS LP Q3 2018 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $15.18B across 97 positions in their Q3 2018 SEC 13F filing (period ending 2018-09-30). Top holdings include SE ($3.94B), INCY ($2.37B), ONC ($2.06B). The top 10 positions account for 84.7% of the portfolio. This quarter saw 6 new positions, 15 increases, 22 reductions, 156 complete exits. Notable new buys: Principia Biopharma Inc. ($52.24M), VKTX ($7.40M), YMAB ($3.98M). Notable exits: NVAX, Aegerion Pharmaceuticals, Inc., Sesen Bio, Inc..

All Holdings

#StockValue↓WeightChange
1
SESeattle Genetics, Inc.
COM
$3.94B
25.93%
-
2
INCYIncyte Corporation
COM
$2.37B
15.59%
+0.0%
3
ONCBeiGene, Ltd.
SPONSORED ADR
$2.06B
13.57%
-
4
Alexion Pharmaceuticals, Inc.
COM
$1.19B
7.83%
-
5
THCHGenomic Health, Inc.
COM
$968.40M
6.38%
+0.0%
6
BMRNBioMarin Pharmaceutical Inc.
COM
$735.33M
4.84%
-
7
ACADACADIA Pharmaceuticals Inc.
COM
$590.40M
3.89%
+4.4%
8
AMRNAmarin Corporation plc
SPONSORED ADR
$554.31M
3.65%
+50.3%
9
MDGLMadrigal Pharmaceuticals, Inc.
COM
$250.38M
1.65%
-
10
ASNDAscendis Pharma A/S
SPONSORED ADR
$201.06M
1.32%
-
11
HRTXHeron Therapeutics, Inc.
COM
$159.05M
1.05%
-
12
Invitae Corporation
COM
$140.52M
0.93%
-
13
DBV Technologies S.A.
SPONSORED ADR
$123.75M
0.82%
-
14
ATIMirati Therapeutics, Inc.
COM
$118.38M
0.78%
-
15
NBIXNeurocrine Biosciences, Inc.
COM
$116.14M
0.77%
-
16
BCRXBioCryst Pharmaceuticals, Inc.
COM
$115.24M
0.76%
+7.8%
17
ARRYArray BioPharma Inc.
COM
$85.97M
0.57%
-
18
SAGESage Therapeutics, Inc.
COM
$80.16M
0.53%
-7.5%
19
RYTMRhythm Pharmaceuticals, Inc.
COM
$79.00M
0.52%
-
20
CERSCerus Corporation
COM
$77.51M
0.51%
-
21
ARGXargenx SE
SPONSORED ADR
$77.32M
0.51%
+6.0%
22
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$76.50M
0.50%
-
23
PARSpark Therapeutics, Inc.
COM
$75.50M
0.50%
-
24
GW Pharmaceuticals plc
ADS
$68.53M
0.45%
+23.3%
25
THCHCymaBay Therapeutics, Inc.
COM
$54.49M
0.36%
-
26
Principia Biopharma Inc.
COM
$52.24M
0.34%
New
27
Tricida, Inc.
COM
$48.88M
0.32%
-
28
NDOIEndocyte, Inc.
COM
$45.25M
0.30%
+11.9%
29
Idera Pharmaceuticals, Inc.
COM
$43.07M
0.28%
-87.5%
30
Corsicanto II Designated Activity Company
NOTE 3.5% 1/5/2047
$41.75M
0.27%
-
31
INSMInsmed Incorporated
COM PAR $.01
$37.45M
0.25%
+164.6%
32
Aquinox Pharmaceuticals, Inc.
COM
$32.04M
0.21%
-
33
ABEOAbeona Therapeutics Inc.
COM
$27.96M
0.18%
-
34
SLDBSolid Biosciences Inc.
COM
$27.74M
0.18%
-
35
GLPGGalapagos NV
SPONSORED ADR
$26.67M
0.18%
-8.7%
36
XNCRXencor, Inc.
COM
$23.48M
0.15%
-30.9%
37
MyoKardia, Inc.
COM
$23.29M
0.15%
-17.5%
38
MRUSMerus N.V.
COM
$22.90M
0.15%
-
39
QUREuniQure N.V.
SHS
$22.02M
0.15%
-
40
SGMOSangamo Therapeutics, Inc.
COM
$21.76M
0.14%
-
41
Clementia Pharmaceuticals Inc.
COM
$21.56M
0.14%
+62.1%
42
ZYMEZymeworks Inc.
COM
$20.58M
0.14%
-
43
THCHAimmune Therapeutics, Inc.
COM
$18.38M
0.12%
-
44
NBIXNeurocrine Biosciences, Inc.
NOTE 2.25% 5/15/2024
$17.06M
0.11%
-
45
Bellicum Pharmaceuticals, Inc.
COM
$16.50M
0.11%
-34.6%
46
BMRNBioMarin Pharmaceutical Inc.
NOTE 0.599% 8/1/2024
$15.82M
0.10%
-
47
THCHAudentes Therapeutics, Inc.
COM
$15.57M
0.10%
-
48
ContraFect Corporation
COM
$14.81M
0.10%
-
49
THCHAeglea BioTherapeutics, Inc.
COM
$13.28M
0.09%
-
50
BMRNBioMarin Pharmaceutical Inc.
NOTE 0.75% 10/15/2018
$12.60M
0.08%
-
Showing 1-50 of 97

Position Changes

StockValueShares
Principia Biopharma Inc.
$52.24M1,787,807
VKTXViking Therapeutics, Inc.
$7.40M425,000
YMABY-mAbs Therapeutics, Inc.
$3.98M150,000
CRNXCrinetics Pharmaceuticals, Inc.
$3.76M131,250
AQSTAquestive Therapeutics, Inc.
$1.74M99,600
ATIConstellation Pharmaceuticals, Inc.
$897.00K133,333