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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $13.31B
Positions: 119
Period: 2018-06-30
Filed: 2018-08-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$13.31B

Positions

119

New

11

Increased

16

Decreased

23

Sold Out

128

BAKER BROS. ADVISORS LP Q2 2018 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $13.31B across 119 positions in their Q2 2018 SEC 13F filing (period ending 2018-06-30). Top holdings include SE ($3.39B), INCY ($2.29B), ONC ($1.84B). The top 10 positions account for 83.6% of the portfolio. This quarter saw 11 new positions, 16 increases, 23 reductions, 128 complete exits. Notable new buys: KNSA ($52.05M), Idera Pharmaceuticals, Inc. ($51.02M), Tricida, Inc. ($47.84M). Notable exits: Idera Pharmaceuticals, Inc., ATI, ABQQ.

All Holdings

#StockValue↓WeightChange
1
SESeattle Genetics, Inc.
COM
$3.39B
25.46%
+3.0%
2
INCYIncyte Corporation
COM
$2.29B
17.24%
+0.1%
3
ONCBeiGene, Ltd.
SPONSORED ADR
$1.84B
13.81%
+105.2%
4
Alexion Pharmaceuticals, Inc.
COM
$1.06B
7.98%
-
5
BMRNBioMarin Pharmaceutical Inc.
COM
$714.33M
5.37%
-
6
THCHGenomic Health, Inc.
COM
$695.04M
5.22%
+0.0%
7
ACADACADIA Pharmaceuticals Inc.
COM
$415.78M
3.12%
-
8
MDGLMadrigal Pharmaceuticals, Inc.
COM
$327.04M
2.46%
+89.9%
9
HRTXHeron Therapeutics, Inc.
COM
$195.23M
1.47%
-
10
ASNDAscendis Pharma A/S
SPONSORED ADR
$188.74M
1.42%
-
11
ATIMirati Therapeutics, Inc.
COM
$123.91M
0.93%
-1.4%
12
PARSpark Therapeutics, Inc.
COM
$114.55M
0.86%
-
13
DBV Technologies S.A.
SPONSORED ADR
$106.28M
0.80%
-
14
SAGESage Therapeutics, Inc.
COM
$96.00M
0.72%
-5.2%
15
ARRYArray BioPharma Inc.
COM
$94.91M
0.71%
-
16
NBIXNeurocrine Biosciences, Inc.
COM
$92.80M
0.70%
-
17
RYTMRhythm Pharmaceuticals, Inc.
COM
$84.66M
0.64%
+32.2%
18
BCRXBioCryst Pharmaceuticals, Inc.
COM
$80.29M
0.60%
-
19
ARGXargenx SE
SPONSORED ADR
$79.69M
0.60%
-
20
CERSCerus Corporation
COM
$71.70M
0.54%
-
21
AMRNAmarin Corporation plc
SPONSORED ADR NEW
$70.05M
0.53%
-
22
THCHCymaBay Therapeutics, Inc.
COM
$66.00M
0.50%
+25.5%
23
Invitae Corporation
COM
$61.74M
0.46%
-
24
KNSAKiniksa Pharmaceuticals, Ltd.
COM CL A
$52.05M
0.39%
New
25
Idera Pharmaceuticals, Inc.
COM NEW
$51.02M
0.38%
New
26
Tricida, Inc.
COM
$47.84M
0.36%
New
27
GW Pharmaceuticals plc
ADS
$44.90M
0.34%
+45.1%
28
NVAXNovavax, Inc.
NOTE 3.75% 2/1/23
$42.67M
0.32%
-16.9%
29
ABEOAbeona Therapeutics Inc.
COM
$34.95M
0.26%
-
30
ERYTECH Pharma S.A.
SPONSORED ADR
$34.47M
0.26%
-0.1%
31
XNCRXencor, Inc.
COM
$32.27M
0.24%
-
32
NDOIEndocyte, Inc.
COM
$31.43M
0.24%
-
33
BLUEbluebird bio, Inc.
COM
$31.39M
0.24%
-
34
Bellicum Pharmaceuticals, Inc.
COM
$30.21M
0.23%
-1.4%
35
Aquinox Pharmaceuticals, Inc.
COM
$28.98M
0.22%
-
36
MRUSMerus N.V.
COM
$26.40M
0.20%
-
37
GLPGGalapagos NV
SPONSORED ADR
$23.96M
0.18%
-
38
QUREuniQure N.V.
SHS
$22.87M
0.17%
+21.0%
39
HALOHalozyme Therapeutics, Inc.
COM
$21.66M
0.16%
-18.8%
40
MyoKardia, Inc.
COM
$21.50M
0.16%
+49.2%
41
SLDBSolid Biosciences Inc.
COM
$20.95M
0.16%
-
42
ZYMEZymeworks Inc.
COM
$19.38M
0.15%
New
43
SGMOSangamo Therapeutics, Inc.
COM
$18.23M
0.14%
-20.1%
44
THCHAimmune Therapeutics, Inc.
COM
$18.12M
0.14%
-
45
INSMInsmed Incorporated
COM PAR $.01
$16.55M
0.12%
-
46
ContraFect Corporation
COM
$15.81M
0.12%
-
47
Clementia Pharmaceuticals Inc.
COM
$15.70M
0.12%
+377.0%
48
BMRNBioMarin Pharmaceutical Inc.
NOTE 0.599% 8/1/2024
$15.20M
0.11%
-
49
THCHAudentes Therapeutics, Inc.
COM
$15.03M
0.11%
-
50
NTLAIntellia Therapeutics, Inc.
COM
$14.96M
0.11%
-34.4%
Showing 1-50 of 119

Position Changes

StockValueShares
KNSAKiniksa Pharmaceuticals, Ltd.
$52.05M3,000,000
Idera Pharmaceuticals, Inc.
$51.02M38,654,811
Tricida, Inc.
$47.84M1,600,000
ZYMEZymeworks Inc.
$19.38M1,311,085
NBIXNeurocrine Biosciences, Inc.
$14.47M10,000,000
GLMDGalmed Pharmaceuticals Ltd.
$7.57M636,140
AUTLAutolus Therapeutics plc
$6.30M235,294
Sesen Bio, Inc.
$5.12M2,624,412
APLSApellis Pharmaceuticals, Inc.
$4.31M196,078
Forty Seven, Inc.
$4.00M250,000
RCUSArcus Biosciences, Inc.
$1.49M121,534