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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $11.80B
Positions: 114
Period: 2018-03-31
Filed: 2018-05-15
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$11.80B

Positions

114

New

7

Increased

21

Decreased

20

Sold Out

122

BAKER BROS. ADVISORS LP Q1 2018 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $11.80B across 114 positions in their Q1 2018 SEC 13F filing (period ending 2018-03-31). Top holdings include INCY ($2.85B), SE ($2.59B), ONC ($979.34M). The top 10 positions account for 80.7% of the portfolio. This quarter saw 7 new positions, 21 increases, 20 reductions, 122 complete exits. Notable new buys: THCH ($26.31M), THCH ($11.82M), Corsicanto II Designated Activity Company ($11.03M). Notable exits: THCH, PLX, ITT.

All Holdings

#StockValue↓WeightChange
1
INCYIncyte Corporation
COM
$2.85B
24.18%
+0.0%
2
SESeattle Genetics, Inc.
COM
$2.59B
21.99%
+8.4%
3
ONCBeiGene, Ltd.
SPONSORED ADR
$979.34M
8.30%
+51.4%
4
Alexion Pharmaceuticals, Inc.
COM
$953.64M
8.08%
+0.0%
5
BMRNBioMarin Pharmaceutical Inc.
COM
$614.76M
5.21%
-
6
ACADACADIA Pharmaceuticals Inc.
COM
$611.82M
5.19%
-
7
THCHGenomic Health, Inc.
COM
$431.49M
3.66%
+0.1%
8
ASNDAscendis Pharma A/S
SPONSORED ADR
$185.56M
1.57%
+8.3%
9
Aquinox Pharmaceuticals, Inc.
COM
$153.95M
1.30%
-
10
AveXis, Inc.
COM
$144.24M
1.22%
+50.6%
11
HRTXHeron Therapeutics, Inc.
COM
$138.70M
1.18%
+64.2%
12
DBV Technologies S.A.
SPONSORED ADR
$127.11M
1.08%
-
13
ABQQAblynx NV
SPONSORED ADR
$118.77M
1.01%
-47.7%
14
SAGESage Therapeutics, Inc.
COM
$104.19M
0.88%
+4.9%
15
ARRYArray BioPharma Inc.
COM
$92.31M
0.78%
-
16
PARSpark Therapeutics, Inc.
COM
$92.17M
0.78%
-
17
NBIXNeurocrine Biosciences, Inc.
COM
$78.34M
0.66%
-6.0%
18
ATIMirati Therapeutics, Inc.
COM
$78.27M
0.66%
-
19
ARGXargenx SE
SPONSORED ADR
$77.36M
0.66%
-
20
MDGLMadrigal Pharmaceuticals, Inc.
COM
$71.91M
0.61%
-
21
Idera Pharmaceuticals, Inc.
COM NEW
$71.10M
0.60%
+111.0%
22
AMRNAmarin Corporation plc
SPONSORED ADR NEW
$68.23M
0.58%
-
23
BCRXBioCryst Pharmaceuticals, Inc.
COM
$66.84M
0.57%
+0.1%
24
ERYTECH Pharma S.A.
SPONSORED ADR
$64.89M
0.55%
-
25
NVAXNovavax, Inc.
Note 3.75% 2/1/2023
$61.86M
0.52%
-
26
CERSCerus Corporation
COM
$58.91M
0.50%
+10.3%
27
THCHCymaBay Therapeutics, Inc.
COM
$50.89M
0.43%
+30.9%
28
RYTMRhythm Pharmaceuticals, Inc.
COM NEW
$40.77M
0.35%
-
29
Invitae Corporation
COM
$39.39M
0.33%
+15.2%
30
BLUEbluebird bio, Inc.
COM
$34.15M
0.29%
-
31
ABEOAbeona Therapeutics Inc.
COM
$31.35M
0.27%
+10.1%
32
HALOHalozyme Therapeutics, Inc.
COM
$30.98M
0.26%
-
33
SGMOSangamo Therapeutics, Inc.
COM
$30.54M
0.26%
-23.9%
34
NKTRNektar Therapeutics
COM
$29.26M
0.25%
+60.2%
35
Bellicum Pharmaceuticals, Inc.
COM
$27.23M
0.23%
-17.5%
36
THCHMenlo Therapeutics Inc.
COM
$26.31M
0.22%
New
37
XNCRXencor, Inc.
COM
$26.14M
0.22%
-
38
GLPGGalapagos NV
SPONSORED ADR
$25.93M
0.22%
-
39
EXELExelixis, Inc.
COM
$25.75M
0.22%
-22.8%
40
GW Pharmaceuticals plc
ADS
$24.99M
0.21%
-
41
MRUSMerus N.V.
COM
$21.50M
0.18%
-
42
THCHAimmune Therapeutics, Inc.
COM
$21.45M
0.18%
-
43
NDOIEndocyte, Inc.
COM
$20.70M
0.18%
+109.5%
44
NTLAIntellia Therapeutics, Inc.
COM
$17.59M
0.15%
-27.2%
45
PRGProgenics Pharmaceuticals, Inc.
COM
$17.20M
0.15%
-26.8%
46
INSMInsmed Incorporated
COM PAR $.01
$15.76M
0.13%
-
47
MyoKardia, Inc.
COM
$14.16M
0.12%
-18.3%
48
BMRNBioMarin Pharmaceutical Inc.
NOTE 0.599% 8/1/2024
$14.10M
0.12%
-
49
BMRNBioMarin Pharmaceutical Inc.
NOTE 0.75% 10/15/2018
$12.54M
0.11%
-
50
THCHAudentes Therapeutics, Inc.
COM
$11.82M
0.10%
New
Showing 1-50 of 114

Position Changes

StockValueShares
THCHMenlo Therapeutics Inc.
$26.31M700,000
THCHAudentes Therapeutics, Inc.
$11.82M393,222
Corsicanto II Designated Activity Company
$11.03M10,000,000
THCHG1 Therapeutics, Inc.
$6.28M169,492
MNTAMomenta Pharmaceuticals, Inc.
$5.60M308,500
SLDBSolid Biosciences Inc.
$4.41M587,884
ITTRitter Pharmaceuticals, Inc.
$762.00K279,999