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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $11.02B
Positions: 134
Period: 2016-09-30
Filed: 2016-11-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$11.02B

Positions

134

New

8

Increased

16

Decreased

15

Sold Out

65

BAKER BROS. ADVISORS LP Q3 2016 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $11.02B across 134 positions in their Q3 2016 SEC 13F filing (period ending 2016-09-30). Top holdings include SE ($2.38B), INCY ($2.22B), ABBV ($904.64M). The top 10 positions account for 83.4% of the portfolio. This quarter saw 8 new positions, 16 increases, 15 reductions, 65 complete exits. Notable new buys: ContraFect Corporation ($10.03M), ATI ($6.71M), Sunesis Pharmaceuticals, Inc. ($3.24M). Notable exits: XenoPort, Inc. Notes 2.5% 2/1/2022, Exelixis, Inc. Notes 4.25% 8/15/2019, Corsicanto Ltd. 3.5% 1/15/2032.

All Holdings

#StockValue↓WeightChange
1
SESeattle Genetics, Inc.
COM
$2.38B
21.61%
+2.0%
2
INCYIncyte Corporation
COM
$2.22B
20.11%
+0.0%
3
ABBVAbbVie Inc.
COM
$904.64M
8.21%
-0.2%
4
ACADACADIA Pharmaceuticals Inc.
COM
$821.33M
7.45%
+5.3%
5
Alexion Pharmaceuticals, Inc.
COM
$801.82M
7.28%
-
6
ATIIncyte Corporation Notes 1.25% 11/15/2020 144A
NOTE 1.25% 11/15/2020
$531.24M
4.82%
-
7
ATIIncyte Corporation Notes 0.375% 11/15/2018 144A
NOTE 0.375% 11/15/2018
$491.34M
4.46%
-
8
BMRNBioMarin Pharmaceutical Inc.
COM
$444.70M
4.04%
-
9
THCHGenomic Health, Inc.
COM
$398.24M
3.61%
+0.7%
10
DBV Technologies S.A.
SPONSORED ADR
$200.16M
1.82%
-
11
Aquinox Pharmaceuticals, Inc.
COM
$140.76M
1.28%
+35.9%
12
BMRNBioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017
NOTE 1.875% 4/23/2017
$101.41M
0.92%
-
13
Bellicum Pharmaceuticals, Inc.
COM
$96.83M
0.88%
-
14
CERSCerus Corporation
COM
$81.06M
0.74%
-3.7%
15
PARSpark Therapeutics, Inc.
COM
$79.18M
0.72%
-
16
THCHAcorda Therapeutics, Inc.
COM
$76.44M
0.69%
-
17
OLOClovis Oncology, Inc. 2.5% 9/15/2021
NOTE 2.5% 9/15/2021
$69.14M
0.63%
-
18
AMRNAmarin Corporation plc
SPONSORED ADR NEW
$65.81M
0.60%
+2472.8%
19
EXELExelixis, Inc.
COM
$63.05M
0.57%
+91.1%
20
THCHAcorda Therapeutics, Inc. Notes 1.75% 6/15/2021
NOTE 1.75% 6/15/2021
$62.83M
0.57%
-
21
ONCBeiGene, Ltd.
SPONSORED ADR
$58.93M
0.53%
-
22
Invitae Corporation
COM
$57.42M
0.52%
-
23
HRTXHeron Therapeutics, Inc.
COM
$49.23M
0.45%
-
24
BCRXBioCryst Pharmaceuticals, Inc.
COM
$48.35M
0.44%
-27.0%
25
NBIXNeurocrine Biosciences, Inc.
COM
$45.34M
0.41%
-
26
PPLAdvanced Accelerator Applications S.A.
SPONSORED ADR
$39.19M
0.36%
+23.5%
27
Versartis, Inc.
COM
$26.14M
0.24%
-21.6%
28
PRGProgenics Pharmaceuticals, Inc.
COM
$23.11M
0.21%
-8.0%
29
Foamix Pharmaceuticals Ltd.
SHS
$22.84M
0.21%
+10.0%
30
ARRYArray BioPharma Inc.
COM
$22.35M
0.20%
-23.2%
31
XNCRXencor, Inc.
COM
$21.36M
0.19%
-
32
HALOHalozyme Therapeutics, Inc.
COM
$20.91M
0.19%
-5.8%
33
Achillion Pharmaceuticals, Inc.
COM
$20.05M
0.18%
-
34
BLUEbluebird bio, Inc.
COM
$19.92M
0.18%
-
35
MRUSMerus N.V.
COM
$19.43M
0.18%
+3.3%
36
SGMOSangamo BioSciences, Inc.
COM
$18.78M
0.17%
-
37
NTLAIntellia Therapeutics, Inc.
COM
$18.08M
0.16%
-
38
Idera Pharmaceuticals, Inc.
COM NEW
$17.96M
0.16%
+0.2%
39
Derma Sciences, Inc.
COM PAR $.01
$17.52M
0.16%
-
40
Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019
NOTE 2.0% 8/15/2019
$17.43M
0.16%
-
41
GLPGGalapagos NV
SPONSORED ADR
$16.80M
0.15%
-
42
TGTXTG Therapeutics, Inc.
COM
$15.51M
0.14%
-
43
ATIMirati Therapeutics, Inc.
COM
$15.00M
0.14%
-
44
ASNDAscendis Pharma A/S
SPONSORED ADR
$14.98M
0.14%
-
45
BMRNBioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018
NOTE 0.75% 10/15/2018
$14.63M
0.13%
-
46
ARWRArrowhead Pharmaceuticals, Inc.
COM
$13.65M
0.12%
+83.9%
47
Vitae Pharmaceuticals, Inc.
COM
$13.34M
0.12%
-
48
ALKSAlkermes plc
SHS
$11.77M
0.11%
-
49
NODKZogenix, Inc.
COM NEW
$11.43M
0.10%
-
50
AERIEURAerie Pharmaceuticals, Inc.
COM
$11.30M
0.10%
-
Showing 1-50 of 134

Position Changes

StockValueShares
ContraFect Corporation
$10.03M4,045,876
ATIInotek Pharmaceuticals Corporation Notes 5.75% 8/1/2021
$6.71M5,000,000
Sunesis Pharmaceuticals, Inc.
$3.24M741,665
MyoKardia, Inc.
$1.63M100,000
LCIDCoLucid Pharmaceuticals, Inc.
$1.16M30,310
FLGTFulgent Genetics, Inc.
$1.15M125,000
MDGLMadrigal Pharmaceuticals, Inc.
$732.00K57,762
ABEOAbeona Therapeutics Inc.
$610.00K101,680