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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $9.48B
Positions: 134
Period: 2016-03-31
Filed: 2016-05-16
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$9.48B

Positions

134

New

8

Increased

31

Decreased

7

Sold Out

48

BAKER BROS. ADVISORS LP Q1 2016 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $9.48B across 134 positions in their Q1 2016 SEC 13F filing (period ending 2016-03-31). Top holdings include INCY ($1.70B), SE ($1.52B), Alexion Pharmaceuticals, Inc. ($910.86M). The top 10 positions account for 78.8% of the portfolio. This quarter saw 8 new positions, 31 increases, 7 reductions, 48 complete exits. Notable new buys: Xenoport, Inc. Notes 2.5% 2/1/2022 ($73.44M), ONC ($56.06M), EXEL ($10.32M). Notable exits: Dyax Corp., IESC, SE.

All Holdings

#StockValue↓WeightChange
1
INCYIncyte Corporation
COM
$1.70B
17.96%
+20.7%
2
SESeattle Genetics, Inc.
COM
$1.52B
16.00%
+15.9%
3
Alexion Pharmaceuticals, Inc.
COM
$910.86M
9.61%
-
4
ABBVAbbVie Inc.
COM
$821.02M
8.66%
-
5
ACADACADIA Pharmaceuticals Inc.
COM
$677.02M
7.14%
+18.2%
6
ATIIncyte Corporation Notes 1.25% 11/15/2020 144A
NOTE 1.25% 11/15/2020
$432.15M
4.56%
-
7
ATIIncyte Corporation Notes 0.375% 11/15/2018 144A
NOTE 0.375% 11/15/2018
$397.94M
4.20%
-
8
BMRNBioMarin Pharmaceutical Inc.
COM
$396.44M
4.18%
+16.8%
9
THCHGenomic Health, Inc.
COM
$338.35M
3.57%
+0.0%
10
Anacor Pharmaceuticals, Inc.
COM
$273.79M
2.89%
+22.0%
11
DBV Technologies S.A.
SPONSORED ADR
$179.34M
1.89%
+0.9%
12
THCHAcorda Therapeutics, Inc.
COM
$96.84M
1.02%
+2.3%
13
BMRNBioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017
NOTE 1.875% 4/23/2017
$89.83M
0.95%
-
14
OLOClovis Oncology Inc. 2.5% 9/15/2021
NOTE 2.5% 9/15/2021
$87.80M
0.93%
-
15
Gilead Sciences, Inc. 1.625% 5/1/16
NOTE 1.625% 5/1/2016
$85.86M
0.91%
-
16
CERSCerus Corporation
COM
$80.37M
0.85%
-
17
Anacor Pharmaceuticals Inc. 2.0% 15 OCT 2021
NOTE 2.0% 10/15/2021
$75.34M
0.79%
-
18
Xenoport, Inc. Notes 2.5% 2/1/2022
NOTE 2.5% 2/1/2022
$73.44M
0.77%
New
19
ATIMirati Therapeutics, Inc.
COM
$69.95M
0.74%
+10.6%
20
THCHAcorda Therapeutics, Inc. Notes 1.75% 6/15/2021
NOTE 1.75% 6/15/2021
$68.46M
0.72%
+49.4%
21
Aquinox Pharmaceuticals, Inc.
COM
$68.38M
0.72%
+14.9%
22
Invitae Corporation
COM
$67.06M
0.71%
-
23
ONCBeiGene, Ltd.
SPONSORED ADR
$56.06M
0.59%
New
24
HRTXHeron Therapeutics, Inc.
COM
$55.22M
0.58%
-
25
Bellicum Pharmaceuticals, Inc.
COM
$45.49M
0.48%
-
26
BCRXBioCryst Pharmaceuticals, Inc.
COM
$42.48M
0.45%
+5.6%
27
ImmunoGen, Inc.
COM
$37.94M
0.40%
-
28
PARSpark Therapeutics, Inc.
COM
$37.25M
0.39%
-
29
NBIXNeurocrine Biosciences, Inc.
COM
$35.41M
0.37%
+5.3%
30
Versartis, Inc.
COM
$25.66M
0.27%
-1.3%
31
SGMOSangamo BioSciences, Inc.
COM
$24.54M
0.26%
-
32
PPLAdvanced Accelerator Applications S.A.
SPONSORED ADR
$21.54M
0.23%
+8.4%
33
Exelixis, Inc. Notes 4.25% 8/15/2019
NOTE 4.25% 8/15/2019
$19.77M
0.21%
-
34
Achillion Pharmaceuticals, Inc.
COM
$19.11M
0.20%
+23.8%
35
INSMInsmed Incorporated
COM PAR $.01
$19.00M
0.20%
+50.0%
36
PRGProgenics Pharmaceuticals, Inc.
COM
$18.97M
0.20%
-
37
HALOHalozyme Therapeutics, Inc.
COM
$18.29M
0.19%
-
38
TGTXTG Therapeutics, Inc.
COM
$17.07M
0.18%
-
39
APGIntra-Cellular Therapies, Inc.
COM
$16.93M
0.18%
-
40
XenoPort, Inc.
COM
$15.68M
0.17%
-
41
ATIMedivation, Inc.
COM
$15.17M
0.16%
-50.0%
42
BLUEbluebird bio, Inc.
COM
$15.00M
0.16%
+150.1%
43
Foamix Pharmaceuticals Ltd.
SHS
$14.62M
0.15%
+9.5%
44
BMRNBioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018
NOTE 0.75% 10/15/2018
$14.13M
0.15%
-
45
Idera Pharmaceuticals, Inc.
COM NEW
$13.84M
0.15%
+0.1%
46
Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019
NOTE 2.0% 8/15/2019
$13.53M
0.14%
-
47
ARRYArray BioPharma Inc.
COM
$12.72M
0.13%
-
48
GLPGGalapagos NV
SPONSORED ADR
$12.69M
0.13%
-17.8%
49
AGIOAgios Pharmaceuticals, Inc.
COM
$12.50M
0.13%
+207.9%
50
NVAXNovavax, Inc.
COM
$12.28M
0.13%
+8.4%
Showing 1-50 of 134

Position Changes

StockValueShares
Xenoport, Inc. Notes 2.5% 2/1/2022
$73.44M100,000,000
ONCBeiGene, Ltd.
$56.06M1,912,680
EXELExelixis, Inc.
$10.32M2,580,000
ARWRArrowhead Pharmaceuticals, Inc.
$4.87M1,009,509
THCHInVivo Therapeutics Holdings Corp.
$2.79M400,000
Adamas Pharmaceuticals, Inc.
$2.50M172,630
GW Pharmaceuticals plc
$1.08M15,000
IESCDiscovery Laboratories, Inc.
$426.00K254,973