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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $10.82B
Positions: 133
Period: 2015-09-30
Filed: 2015-11-16
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$10.82B

Positions

133

New

16

Increased

27

Decreased

8

Sold Out

33

BAKER BROS. ADVISORS LP Q3 2015 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $10.82B across 133 positions in their Q3 2015 SEC 13F filing (period ending 2015-09-30). Top holdings include INCY ($2.15B), SE ($1.39B), Alexion Pharmaceuticals, Inc. ($1.02B). The top 10 positions account for 77.5% of the portfolio. This quarter saw 16 new positions, 27 increases, 8 reductions, 33 complete exits. Notable new buys: OLO ($215.31M), ATI ($28.04M), NODK ($24.28M). Notable exits: ATI, ATI, XOMA Corporation.

All Holdings

#StockValue↓WeightChange
1
INCYIncyte Corporation
COM
$2.15B
19.85%
+31.0%
2
SESeattle Genetics, Inc.
COM
$1.39B
12.84%
+16.7%
3
Alexion Pharmaceuticals, Inc.
COM
$1.02B
9.45%
-
4
ABBVAbbVie Inc.
COM
$782.06M
7.23%
-
5
ACADACADIA Pharmaceuticals Inc.
COM
$677.32M
6.26%
-
6
ATIIncyte Corporation Notes 1.25% 11/15/2020 144A
CONV BONDS
$598.70M
5.53%
-
7
ATIIncyte Corporation Notes 0.375% 11/15/2018 144A
CONV BONDS
$559.64M
5.17%
-
8
Anacor Pharmaceuticals, Inc.
COM
$486.78M
4.50%
+14.1%
9
BMRNBioMarin Pharmaceutical Inc.
COM
$429.32M
3.97%
-0.5%
10
THCHGenomic Health Inc.
COM
$289.01M
2.67%
+0.0%
11
OLOClovis Oncology Inc. 2.5% 9/15/2021
CONV BONDS
$215.31M
1.99%
New
12
DBV Technologies S.A.
SPONSORED ADR
$194.39M
1.80%
+193.3%
13
BCRXBioCryst Pharmaceuticals, Inc.
COM
$160.86M
1.49%
+21.9%
14
Dyax Corp.
COM
$144.35M
1.33%
-4.6%
15
BMRNBioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017
CONV BONDS
$115.62M
1.07%
-
16
ATIMirati Therapeutics, Inc.
COM
$101.71M
0.94%
+5.3%
17
Aquinox Pharmaceuticals, Inc.
COM
$94.94M
0.88%
+463.5%
18
Gilead, Inc. 1.625% 5/1/16
CONV BONDS
$90.33M
0.83%
-
19
HRTXHeron Therapeutics, Inc.
COM
$70.95M
0.66%
+3.6%
20
CERSCerus Corporation
COM
$61.53M
0.57%
-
21
Bellicum Pharmaceuticals, Inc.
COM
$60.89M
0.56%
-
22
THCHAcorda Therapeutics, Inc. Notes 1.75% 6/15/2021
CONV BONDS
$54.12M
0.50%
-
23
PARSpark Therapeutics, Inc.
COM
$52.68M
0.49%
-
24
Invitae Corporation
COM
$47.33M
0.44%
-
25
Versartis, Inc.
COM
$37.38M
0.35%
-5.7%
26
ImmunoGen, Inc.
COM
$34.06M
0.31%
+52.9%
27
NBIXNeurocrine Biosciences, Inc.
COM
$29.87M
0.28%
+38.5%
28
INSMInsmed, Inc.
COM PAR $.01
$29.41M
0.27%
-
29
THCHAcorda Therapeutics, Inc.
COM
$29.08M
0.27%
+48.4%
30
ATIMedivation, Inc.
COM
$28.04M
0.26%
New
31
HALOHalozyme Therapeutics, Inc.
COM
$25.93M
0.24%
-
32
PRGProgenics Pharmaceuticals, Inc.
COM
$24.89M
0.23%
-
33
GILDGilead Sciences, Inc.
COM
$24.55M
0.23%
-
34
APGIntra-Cellular Therapies, Inc.
COM
$24.39M
0.23%
+484.8%
35
NODKZogenix, Inc.
COM NEW
$24.28M
0.22%
New
36
Exelisis, Inc. Notes 4.25% 8/15/2019
CONV BONDS
$23.99M
0.22%
New
37
ATYRaTyr Pharma Inc.
COM
$23.96M
0.22%
-
38
Idera Pharmaceuticals, Inc.
COM NEW
$23.37M
0.22%
+0.1%
39
XenoPort, Inc.
COM
$22.59M
0.21%
-
40
CPRXCatalyst Pharmaceuticals, Inc.
COM
$22.01M
0.20%
-
41
SGMOSangamo BioSciences, Inc.
COM
$21.18M
0.20%
+16.2%
42
TGTXTG Therapeutics, Inc.
COM
$20.20M
0.19%
-
43
Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019
CONV BONDS
$19.87M
0.18%
New
44
ARRYArray BioPharma Inc.
COM
$19.66M
0.18%
-21.4%
45
OLOClovis Oncology, Inc.
COM
$18.63M
0.17%
-
46
Alder Biopharmaceuticals Inc.
COM
$16.82M
0.16%
-42.4%
47
Derma Sciences, Inc.
COM PAR $.01
$16.29M
0.15%
-
48
BMRNBioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018
CONV BONDS
$15.90M
0.15%
-
49
NVAXNovavax, Inc.
COM
$15.52M
0.14%
+12.8%
50
GLPGGalapagos NV ADR
SPON ADR
$15.03M
0.14%
-
Showing 1-50 of 133

Position Changes

StockValueShares
OLOClovis Oncology Inc. 2.5% 9/15/2021
$215.31M129,300,000
ATIMedivation, Inc.
$28.04M659,752
NODKZogenix, Inc.
$24.28M1,798,365
Exelisis, Inc. Notes 4.25% 8/15/2019
$23.99M20,000,000
Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019
$19.87M26,517,000
AKTXAkari Therapeutics PLC ADR
$9.50M395,882
THCHGlobal Blood Therapeutics, Inc.
$8.43M200,000
THCHAimmune Therapeutics, Inc.
$6.33M250,000
NDOIEndocyte, Inc.
$6.21M1,356,552
TRVNTrevena, Inc.
$4.66M450,000
THCHPronai Therapeutics, Inc.
$4.10M200,000
THCHNabriva Therapeutics AG
$3.33M350,000
NTRANatera, Inc.
$2.71M250,000
DVAXDynavax Technologies Corporation
$1.84M75,000
ABUSArbutus Biopharma Corporation
$1.10M180,582
THCHTrillium Therapeutics, Inc.
$821.00K63,014