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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $11.40B
Positions: 126
Period: 2015-06-30
Filed: 2015-08-14
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$11.40B

Positions

126

New

10

Increased

24

Decreased

18

Sold Out

24

BAKER BROS. ADVISORS LP Q2 2015 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $11.40B across 126 positions in their Q2 2015 SEC 13F filing (period ending 2015-06-30). Top holdings include INCY ($1.55B), SE ($1.49B), Alexion Pharmaceuticals, Inc. ($1.18B). The top 10 positions account for 75.1% of the portfolio. This quarter saw 10 new positions, 24 increases, 18 reductions, 24 complete exits. Notable new buys: Alexion Pharmaceuticals, Inc. ($1.18B), ABBV ($965.76M), ATYR ($43.25M). Notable exits: Salix Pharmaceuticals Inc. 2.75% 5/15/15, Salix Pharmaceuticals Inc. 1.5% 3/15/19, Synageva Biopharma Corp..

All Holdings

#StockValue↓WeightChange
1
INCYIncyte Corporation
COM
$1.55B
13.59%
+0.1%
2
SESeattle Genetics, Inc.
COM
$1.49B
13.11%
+6.9%
3
Alexion Pharmaceuticals, Inc.
COM
$1.18B
10.37%
New
4
ABBVAbbVie Inc.
COM
$965.76M
8.47%
New
5
ACADACADIA Pharmaceuticals Inc.
COM
$857.76M
7.52%
-
6
ATIIncyte Corporation Notes 1.25% 11/15/2020 144A
CONV BONDS
$567.76M
4.98%
-
7
BMRNBioMarin Pharmaceutical Inc.
COM
$560.15M
4.91%
-2.5%
8
ATIIncyte Corporation Notes 0.375% 11/15/2018 144A
CONV BONDS
$529.52M
4.64%
-
9
ATIIncyte Corporation Notes 4.75% 10/1/2015 144A
CONV BONDS
$478.83M
4.20%
-
10
THCHGenomic Health Inc.
COM
$379.55M
3.33%
+0.0%
11
Anacor Pharmaceuticals, Inc.
COM
$280.72M
2.46%
-13.8%
12
Dyax Corp.
COM
$210.06M
1.84%
+31.6%
13
BCRXBioCryst Pharmaceuticals, Inc.
COM
$172.85M
1.52%
+10.5%
14
BMRNBioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017
CONV BONDS
$149.97M
1.32%
-
15
Gilead, Inc. 1.625% 5/1/16
CONV BONDS
$107.93M
0.95%
-
16
Invitae Corporation
COM
$97.54M
0.86%
-
17
Bellicum Pharmaceuticals, Inc.
COM
$89.13M
0.78%
-
18
ATIMirati Therapeutics, Inc.
COM
$88.28M
0.77%
-
19
HRTXHeron Therapeutics, Inc.
COM
$87.49M
0.77%
+7.7%
20
PARSpark Therapeutics, Inc.
COM
$76.08M
0.67%
-4.9%
21
ATIMedivation, Inc. 2.625% 4/1/17
CONV BONDS
$75.01M
0.66%
-
22
CERSCerus Corporation
COM
$70.34M
0.62%
-
23
THCHAcorda Therapeutics, Inc. Notes 1.75% 6/15/2021
CONV BONDS
$60.05M
0.53%
-
24
XOMA Corporation
COM
$56.97M
0.50%
-0.2%
25
DBV Technologies S.A.
SPONSORED ADR
$55.45M
0.49%
+22.6%
26
Versartis, Inc.
COM
$52.30M
0.46%
+15.4%
27
Alder Biopharmaceuticals Inc.
COM
$47.23M
0.41%
+1.4%
28
HALOHalozyme Therapeutics, Inc.
COM
$43.60M
0.38%
-14.1%
29
ATYRaTyr Pharma Inc.
COM
$43.25M
0.38%
New
30
XenoPort, Inc.
COM
$39.90M
0.35%
-
31
ARRYArray BioPharma Inc.
COM
$39.53M
0.35%
-3.1%
32
INSMInsmed, Inc.
COM
$38.67M
0.34%
-
33
SGMOSangamo BioSciences, Inc.
COM
$35.83M
0.31%
+130.0%
34
ImmunoGen, Inc.
COM
$33.37M
0.29%
+132.2%
35
TGTXTG Therapeutics, Inc.
COM
$33.25M
0.29%
-2.3%
36
PRGProgenics Pharmaceuticals, Inc.
COM
$32.46M
0.28%
-
37
CPRXCatalyst Pharmaceuticals, Inc.
COM
$30.30M
0.27%
-3.0%
38
GILDGilead Sciences, Inc.
COM
$29.27M
0.26%
-
39
THCHKythera Biopharmaceuticals, Inc.
COM
$29.20M
0.26%
+9.4%
40
NBIXNeurocrine Biosciences, Inc.
COM
$25.90M
0.23%
-
41
Idera Pharmaceuticals, Inc.
COM
$25.86M
0.23%
+0.1%
42
BLUEbluebird bio, Inc.
COM
$25.44M
0.22%
+3.1%
43
Derma Sciences, Inc.
COM
$24.76M
0.22%
-
44
THCHAcorda Therapeutics, Inc.
COM
$24.63M
0.22%
-
45
NVAXNovavax, Inc.
COM
$21.68M
0.19%
-
46
Foamix Pharmaceuticals Ltd.
SHS
$20.98M
0.18%
+12.3%
47
XNCRXencor, Inc.
COM
$19.16M
0.17%
-
48
GLPGGalapagos NV
SPONSORED ADR
$19.02M
0.17%
New
49
BMRNBioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018
CONV BONDS
$18.94M
0.17%
-
50
OLOClovis Oncology, Inc.
COM
$17.81M
0.16%
-
Showing 1-50 of 126

Position Changes

StockValueShares
Alexion Pharmaceuticals, Inc.
$1.18B6,542,599
ABBVAbbVie Inc.
$965.76M14,373,538
ATYRaTyr Pharma Inc.
$43.25M2,335,125
GLPGGalapagos NV
$19.02M369,276
MCRBSeres Therapeutics, Inc.
$5.19M125,000
CRISCuris, Inc.
$3.57M1,077,663
Immune Design Corp.
$3.08M148,937
ADAPAdaptimmune Therapeutics plc
$1.83M100,000
ITTRitter Pharmaceuticals, Inc.
$1.78M400,000
TENXTenax Therapeutics Inc.
$1.31M355,348