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BAKER BROS. ADVISORS LP

NEW YORK, NY · CIK 0001263508

Portfolio Value: $12.02B
Positions: 130
Period: 2015-03-31
Filed: 2015-05-15
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022Q3 2022Q2 2022Q1 2022Q4 2021Q3 2021Q2 2021Q1 2021Q4 2020Q3 2020Q2 2020Q1 2020Q4 2019Q3 2019Q2 2019Q1 2019Q4 2018Q3 2018Q2 2018Q1 2018Q4 2017Q3 2017Q2 2017Q1 2017Q4 2016Q3 2016Q2 2016Q1 2016Q4 2015Q3 2015Q2 2015Q1 2015Q4 2014

Portfolio Value

$12.02B

Positions

130

New

19

Increased

23

Decreased

58

Sold Out

10

BAKER BROS. ADVISORS LP Q1 2015 13F Filing Summary

BAKER BROS. ADVISORS LP (NEW YORK, NY) reported a portfolio value of $12.02B across 130 positions in their Q1 2015 SEC 13F filing (period ending 2015-03-31). Top holdings include Pharmacyclics Inc. ($2.31B), INCY ($1.36B), Synageva Biopharma Corp. ($1.14B). The top 10 positions account for 76.7% of the portfolio. This quarter saw 19 new positions, 23 increases, 58 reductions, 10 complete exits. Notable new buys: Invitae Corp. ($109.86M), PAR ($102.88M), IESC ($16.05M). Notable exits: NODK, QLT Inc., Synergy Pharmaceuticals.

All Holdings

#StockValue↓WeightChange
1
Pharmacyclics Inc.
COM
$2.31B
19.24%
-1.0%
2
INCYIncyte Corp.
COM
$1.36B
11.32%
-
3
Synageva Biopharma Corp.
COM
$1.14B
9.46%
+9.4%
4
SESeattle Genetics, Inc.
COM
$1.02B
8.49%
+3.6%
5
Salix Pharmaceuticals Inc. 2.75% 5/15/15
CONV BONDS
$801.15M
6.66%
-1.5%
6
ACADAcadia Pharmaceuticals Inc.
COM
$667.49M
5.55%
-
7
BMRNBiomarin Pharmaceuticals Inc.
COM
$523.46M
4.35%
+13.1%
8
ATIIncyte Corp. Notes 1.25% 11/15/2020 144A
CONV BONDS
$508.43M
4.23%
-
9
ATIIncyte Corp. Notes 0.375% 11/15/2018 144A
CONV BONDS
$471.94M
3.93%
-
10
ATIIncyte Corp. Notes 4.75% 10/1/2015 144A
CONV BONDS
$421.67M
3.51%
-
11
THCHGenomic Health Inc.
COM
$417.22M
3.47%
+0.0%
12
Anacor Pharmaceuticals Inc.
COM
$243.24M
2.02%
-
13
BMRNBiomarin Pharmaceuticals Inc. Notes 1.875% 4/23/2017
CONV BONDS
$136.99M
1.14%
-2.3%
14
Invitae Corp.
COM
$109.86M
0.91%
New
15
PARSpark Therapeutics, Inc.
COM
$102.88M
0.86%
New
16
Dyax Corp.
COM
$100.89M
0.84%
-2.2%
17
Bellicum Pharmaceuticals, Inc.
COM
$97.10M
0.81%
-2.2%
18
BCRXBiocryst Pharmaceuticals Inc.
COM
$94.62M
0.79%
-2.2%
19
Gilead Sciences Inc. 1.625% 5/1/16
CONV BONDS
$90.19M
0.75%
-2.6%
20
ATIMedivation Inc. 2.625% 4/1/17
CONV BONDS
$84.93M
0.71%
-2.4%
21
ATIMirati Therapeutics Inc.
COM
$82.25M
0.68%
+17.9%
22
THCHAcorda Therapeutics Inc. Notes 1.75% 6/15/2021
CONV BONDS
$60.76M
0.51%
-2.2%
23
CERSCerus Corp.
COM
$56.52M
0.47%
+15.8%
24
Versartis Inc.
COM
$54.69M
0.45%
+30.5%
25
Xoma Corp.
COM
$53.54M
0.45%
-13.1%
26
Xenoport Inc.
COM
$46.34M
0.39%
-5.7%
27
ARRYArray Biopharma Inc.
COM
$41.70M
0.35%
+294.7%
28
Salix Pharmaceuticals Inc. 1.5% 3/15/19
CONV BONDS
$38.95M
0.32%
-2.2%
29
HRTXHeron Therapeutics, Inc.
COM
$37.94M
0.32%
-
30
DBV Technologies Inc.
SPONSORED ADR
$35.49M
0.30%
-
31
INSMInsmed Inc.
COM
$32.94M
0.27%
+42.9%
32
CPRXCatalyst Pharmaceuticals, Inc.
COM
$32.76M
0.27%
+12.7%
33
HALOHalozyme Therapeutics Inc.
COM
$32.10M
0.27%
-19.0%
34
TGTXTG Therapeutics Inc.
COM
$31.74M
0.26%
-
35
Derma Sciences Inc.
COM
$29.29M
0.24%
-2.2%
36
PRGProgenics Pharmaceuticals, Inc.
COM
$26.02M
0.22%
-2.2%
37
Idera Pharmaceuticals Inc.
COM
$25.84M
0.21%
+327.8%
38
Alder Biopharmaceuticals Inc.
COM
$25.39M
0.21%
+473.6%
39
THCHAcorda Therapeutics, Inc.
COM
$24.59M
0.20%
-2.2%
40
GILDGilead Sciences Inc.
COM
$24.53M
0.20%
-2.4%
41
SGMOSangamo Biosciences, Inc.
COM
$22.02M
0.18%
+47.0%
42
NBIXNeurocrine Biosciences, Inc.
COM
$21.53M
0.18%
-2.2%
43
BMRNBiomarin Pharmaceuticals Inc. Notes 0.75% 10/15/2018
CONV BONDS
$17.97M
0.15%
-2.2%
44
THCHKythera Biopharmaceuticals Inc.
COM
$17.77M
0.15%
+23.8%
45
BLUEBluebird Bio Inc.
COM
$17.70M
0.15%
-2.3%
46
THCHRepros Therapeutics Inc.
COM
$17.18M
0.14%
-
47
Foamix Pharmaceuticals Ltd.
SHS
$16.85M
0.14%
+78.3%
48
VNDAVanda Pharmaceuticals, Inc.
COM
$16.28M
0.14%
-60.9%
49
NVAXNovavax Inc.
COM
$16.09M
0.13%
+59.0%
50
IESCLion Biotechnologies Inc.
COM
$16.05M
0.13%
New
Showing 1-50 of 130

Position Changes

StockValueShares
Invitae Corp.
$109.86M6,554,967
PARSpark Therapeutics, Inc.
$102.88M1,327,451
IESCLion Biotechnologies Inc.
$16.05M1,325,000
Immunogen, Inc.
$8.95M999,496
THCHTransition Therapeutics, Inc.
$5.25M769,230
AMRNAmarin Corp. PLC
$5.16M2,205,710
ARRYArray Biopharma, Inc. Notes 3.0% 6/1/2020
$3.76M3,000,000
FGOZafgen, Inc.
$3.75M94,745
ASMBAssembly Biosciences, Inc.
$3.31M250,000
THCHBellerophon Therapeutics, Inc.
$3.21M350,000
Auspex Pharmaceuticals, Inc.
$2.51M25,000
APGIntra Cellular Therapies Inc.
$2.49M104,166
Vitae Pharmaceuticals Inc.
$2.20M187,597
ASNDAscendis Pharma SA
$1.74M100,000
CLLSCellectis SA
$1.73M50,000
ALDXAldeyra Therapeutics, Inc.
$1.45M142,000
Ohr Pharmaceuticals, Inc.
$941.00K370,370
Aegerion Pharmaceuticals, Inc.
$374.00K14,300
Biodel Inc.
$36.00K30,179